Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (3) GO Terms (57) Nucleotides (156) Proteins (62) Interactants (444) Wiki
XB-GENEPAGE-943657
???displayGene.symbol???:
 optn

???displayGene.name???: 
optineurin

???displayGene.synonyms???
( Nomenclature history )

???displayGene.geneFunction???
ER-Golgi vesicle tethering

AI Protein Function :
The gene optn encodes an autophagy receptor protein that functions in selective autophagy, including mitophagy and aggrephagy. It localizes to the cytoplasm and interacts with microtubule-associated pr...[+]


InterPro :
NEMO N, CC2-LZ dom, NEMO ZF, Optineurin/NFkB EssMod

???displayGene.geneInteractants???
Loading ...

Diseases: 


Disease Ontology:
amyotrophic lateral sclerosis type 12 [+]

MIM:
GLAUCOMA, PRIMARY OPEN ANGLE; POAG [+]

External Links:
Loading gene data...
Please wait while we fetch the latest information
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info