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Proc Natl Acad Sci U S A
2000 Nov 07;9723:12607-12. doi: 10.1073/pnas.220302597.
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The classical progesterone receptor mediates Xenopus oocyte maturation through a nongenomic mechanism.
Bayaa M, Booth RA, Sheng Y, Liu XJ.
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Xenopus laevis oocytes are physiologically arrested at G(2) of meiosis I. Resumption of meiosis, or oocyte maturation, is triggered by progesterone. Progesterone-induced Xenopus oocyte maturation is mediated via an extranuclear receptor and is independent of gene transcription. The identity of this extranuclear oocyte progesterone receptor (PR), however, has remained a longstanding problem. We have isolated the amphibian homologue of human PR from a Xenopus oocyte cDNA library. The cloned Xenopus progesterone receptor (xPR) functioned in heterologous cells as a progesterone-regulated transcription activator. However, endogenous xPR was excluded from the oocyte nucleus and instead appeared to be a cytosolic protein not associated with any membrane structures. Injection of xPR mRNA into Xenopus oocytes accelerated the progesterone-induced oocyte maturation and reduced the required concentrations of progesterone. In enucleated oocytes, xPR accelerated the progesterone-induced mitogen-activated protein kinase activation. These data suggest that xPR is the long sought after Xenopus oocyte receptor responsible for progesterone-induced oocyte maturation.
Benhamou,
A single amino acid that determines the sensitivity of progesterone receptors to RU486.
1992, Pubmed
Benhamou,
A single amino acid that determines the sensitivity of progesterone receptors to RU486.
1992,
Pubmed Castoria,
Non-transcriptional action of oestradiol and progestin triggers DNA synthesis.
1999,
Pubmed Chesnel,
Comparative effects of insulin on the activation of the Raf/Mos-dependent MAP kinase cascade in vitellogenic versus postvitellogenic Xenopus oocytes.
1997,
Pubmed
,
Xenbase Danielian,
Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.
1992,
Pubmed Gawantka,
Beta 1-integrin is a maternal protein that is inserted into all newly formed plasma membranes during early Xenopus embryogenesis.
1992,
Pubmed
,
Xenbase Godeau,
Induction of maturation in Xenopus laevis oocytes by a steroid linked to a polymer.
1978,
Pubmed
,
Xenbase Green,
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
,
Pubmed Heine,
The Gly/Arg-rich (GAR) domain of Xenopus nucleolin facilitates in vitro nucleic acid binding and in vivo nucleolar localization.
1993,
Pubmed
,
Xenbase Ishikawa,
Primary action of steroid hormone at the surface of amphibian oocyte in the induction of germinal vesicle breakdown.
1977,
Pubmed
,
Xenbase Liu,
Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation.
1995,
Pubmed
,
Xenbase Maller,
Recurring themes in oocyte maturation.
1998,
Pubmed Maller,
The elusive progesterone receptor in Xenopus oocytes.
2001,
Pubmed
,
Xenbase Masui,
Relative roles of the pituitary, follicle cells, and progesterone in the induction of oocyte maturation in Rana pipiens.
1967,
Pubmed Masui,
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.
1971,
Pubmed Methfessel,
Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels.
1986,
Pubmed
,
Xenbase Migliaccio,
Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor.
1998,
Pubmed Misrahi,
Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA.
1987,
Pubmed Mora,
Insulin and insulin-like growth factor I (IGF-I) stimulate GLUT4 glucose transporter translocation in Xenopus oocytes.
1995,
Pubmed
,
Xenbase Ohan,
RHO-associated protein kinase alpha potentiates insulin-induced MAP kinase activation in Xenopus oocytes.
1999,
Pubmed
,
Xenbase Posada,
Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.
1993,
Pubmed
,
Xenbase Posada,
Requirements for phosphorylation of MAP kinase during meiosis in Xenopus oocytes.
1992,
Pubmed
,
Xenbase Préfontaine,
Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter.
1999,
Pubmed Razandi,
Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells.
1999,
Pubmed Rebagliati,
Identification and cloning of localized maternal RNAs from Xenopus eggs.
1985,
Pubmed
,
Xenbase Sadler,
Progesterone inhibits adenylate cyclase in Xenopus oocytes. Action on the guanine nucleotide regulatory protein.
1981,
Pubmed
,
Xenbase Sadler,
Studies of a plasma membrane steroid receptor in Xenopus oocytes using the synthetic progestin RU 486.
1985,
Pubmed
,
Xenbase Sadler,
The development of competence for meiotic maturation during oogenesis in Xenopus laevis.
1983,
Pubmed
,
Xenbase Sagata,
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.
1988,
Pubmed
,
Xenbase Smith,
The interaction of steroids with Rana pipiens Oocytes in the induction of maturation.
1971,
Pubmed Smith,
The induction of oocyte maturation: transmembrane signaling events and regulation of the cell cycle.
1989,
Pubmed Smith,
Oogenesis and oocyte isolation.
1991,
Pubmed
,
Xenbase Stevis,
Differential effects of estradiol and estradiol-BSA conjugates.
1999,
Pubmed Tso,
Microinjected progesterone reinitiates meiotic maturation of Xenopus laevis oocytes.
1982,
Pubmed
,
Xenbase Turner,
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
1994,
Pubmed
,
Xenbase Vegeto,
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor.
1992,
Pubmed Watson,
Membrane-initiated steroid actions and the proteins that mediate them.
1999,
Pubmed
