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XB-ART-10221
FEBS Lett 2000 Sep 29;4821-2:37-43.
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Maternal cold inducible RNA binding protein is required for embryonic kidney formation in Xenopus laevis.

Peng Y, Kok KH, Xu RH, Kwok KH, Tay D, Fung PC, Kung HF, Lin MC.


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We cloned a major isoform of Xenopus homologue of cold inducible RNA binding protein (CIRP), XCIRP-1. XCIRP-1 was neither cold inducible nor essential for cell division during early embryonic development. Suppression of XCIRP-1 dose dependently produced tailbuds with deformations of the brain and internal organs. The defects were XCIRP-1 specific as they could be rescued by sense transcript. Suppression of XCIRP-1 also disrupted the morphogenetic migration of the C3 blastomeres (lineaged to become the embryonic kidney, the pronephros). In animal cap explants, depletion of XCIRP-1 inhibited activin/retinoic acid induced expressions of pronephros related Xlim-1 and WT1 genes. These results suggest that XCIRP-1 is required for the specification and morphogenetic lineage migration of the pronephros.

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Species referenced: Xenopus laevis
Genes referenced: cirbp lhx1 wt1