Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Store-operated calcium entry (SOCE) is the predominant Ca(2+) influx pathway in non-excitable cells and is activated in response to depletion of intracellular Ca(2+) stores. We have studied SOCE regulation during Xenopus oocyte meiosis. SOCE can be measured readily in stage VI Xenopus oocytes arrested at the G(2)-M transition of the cell cycle, either by Ca(2+) imaging or by recording the SOCE current. However, following meiotic maturation, SOCE can no longer be activated by store depletion. We have characterized the time course of SOCE inactivation during oocyte maturation, and show that SOCE inactivates almost completely, in a very short time period, at the germinal vesicle breakdown stage of meiosis. This acute inactivation offers an opportunity to better understand SOCE regulation.
Berridge,
Calcium signalling and cell proliferation.
1995, Pubmed
Berridge,
Calcium signalling and cell proliferation.
1995,
Pubmed Berridge,
Capacitative calcium entry.
1995,
Pubmed Coombs,
Changes in voltage-dependent ion currents during meiosis and first mitosis in eggs of an ascidian.
1992,
Pubmed Csutora,
Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores.
1999,
Pubmed
,
Xenbase Day,
Cell-cycle control of a large-conductance K+ channel in mouse early embryos.
1993,
Pubmed Dolmetsch,
Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes.
1994,
Pubmed Fanger,
Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.
1995,
Pubmed Fomina,
A current activated on depletion of intracellular Ca2+ stores can regulate exocytosis in adrenal chromaffin cells.
1999,
Pubmed Gilon,
The Ca(2+)-mobilizing actions of a Jurkat cell extract on mammalian cells and Xenopus laevis oocytes.
1995,
Pubmed
,
Xenbase Grey,
Formation and structure of the fertilization envelope in Xenopus laevis.
1974,
Pubmed
,
Xenbase Grey,
An electrical block is required to prevent polyspermy in eggs fertilized by natural mating of Xenopus laevis.
1982,
Pubmed
,
Xenbase Hartzell,
Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx.
1996,
Pubmed
,
Xenbase Irvine,
'Quantal' Ca2+ release and the control of Ca2+ entry by inositol phosphates--a possible mechanism.
1990,
Pubmed Koizumi,
Functional coupling of secretion and capacitative calcium entry in PC12 cells.
1998,
Pubmed Machaca,
Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents.
1999,
Pubmed
,
Xenbase Miyazaki,
Calcium signalling during mammalian fertilization.
1995,
Pubmed Neher,
Discrete changes of cell membrane capacitance observed under conditions of enhanced secretion in bovine adrenal chromaffin cells.
1982,
Pubmed Pardo,
Cell cycle-related changes in the conducting properties of r-eag K+ channels.
1998,
Pubmed
,
Xenbase Parekh,
Store depletion and calcium influx.
1997,
Pubmed Preston,
Regulation of Ca2+ influx during mitosis: Ca2+ influx and depletion of intracellular Ca2+ stores are coupled in interphase but not mitosis.
1991,
Pubmed Randriamampita,
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx.
1993,
Pubmed Richter,
Regulatory changes of membrane transport and ouabain binding during progesterone-induced maturation of Xenopus oocytes.
1984,
Pubmed
,
Xenbase Rosado,
A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling.
2000,
Pubmed Schmalzing,
Downregulation of surface sodium pumps by endocytosis during meiotic maturation of Xenopus laevis oocytes.
1990,
Pubmed
,
Xenbase Serafini,
Isolation of mutant T lymphocytes with defects in capacitative calcium entry.
1995,
Pubmed Smith,
The induction of oocyte maturation: transmembrane signaling events and regulation of the cell cycle.
1989,
Pubmed Somasundaram,
Primaquine, an inhibitor of vesicular transport, blocks the calcium-release-activated current in rat megakaryocytes.
1995,
Pubmed Stricker,
Comparative biology of calcium signaling during fertilization and egg activation in animals.
1999,
Pubmed Takahashi,
CFTR-dependent membrane insertion is linked to stimulation of the CFTR chloride conductance.
1996,
Pubmed
,
Xenbase Vasilets,
Activation of protein kinase C by phorbol ester induces downregulation of the Na+/K(+)-ATPase in oocytes of Xenopus laevis.
1990,
Pubmed
,
Xenbase Warren,
Membrane partitioning during cell division.
1993,
Pubmed Wasserman,
Effects of cyclohexamide on a cytoplasmic factor initiating meiotic naturation in Xenopus oocytes.
1975,
Pubmed
,
Xenbase Yao,
Calcium current activated by depletion of calcium stores in Xenopus oocytes.
1997,
Pubmed
,
Xenbase
