Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Neurosci
2000 Aug 01;2015:5802-12. doi: 10.1523/JNEUROSCI.20-15-05802.2000.
Show Gene links
Show Anatomy links
Neocortical origin and tangential migration of guidepost neurons in the lateral olfactory tract.
Tomioka N, Osumi N, Sato Y, Inoue T, Nakamura S, Fujisawa H, Hirata T.
???displayArticle.abstract???
The early-generated neurons designated as lot cells specifically mark the future site of the lateral olfactory tract (LOT) and guide LOT axons. We investigated the mechanism of how lot cells develop and get localized in the LOT position. Lot cells differentiated from neuroepithelial cells in all regions of the neocortex but not from those in the ganglionic eminence in culture. Cell tracing analyses demonstrated that lot cells generated from the neocortex subsequently followed a tangential migration stream ventrally toward the LOT position. Mutant mouse embryos lacking the function of transcription factor Gli3 showed disturbances of the migration stream and translocation of lot cells in the dorsal telencephalon. These results reveal a new type of neuronal migration in the telencephalon and introduce an unexpected dramatic feature of the earliest regionalization of the telencephalon.
Akamatsu,
Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems.
1999, Pubmed
Akamatsu,
Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems.
1999,
Pubmed Anderson,
Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes.
1997,
Pubmed Arimatsu,
Early regional specification for a molecular neuronal phenotype in the rat neocortex.
1992,
Pubmed Barbe,
The early commitment of fetal neurons to the limbic cortex.
1991,
Pubmed Brunjes,
Maturation and plasticity in the olfactory system of vertebrates.
1986,
Pubmed Bulfone,
Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries.
1993,
Pubmed Cohen-Tannoudji,
Early determination of a mouse somatosensory cortex marker.
1994,
Pubmed Davis,
Role of Olf-1 and Pax-6 transcription factors in neurodevelopment.
1996,
Pubmed de Carlos,
Dynamics of cell migration from the lateral ganglionic eminence in the rat.
1996,
Pubmed Dehay,
Modulation of the cell cycle contributes to the parcellation of the primate visual cortex.
1993,
Pubmed Fishell,
Dispersion of neural progenitors within the germinal zones of the forebrain.
1993,
Pubmed Fishell,
Regionalization in the mammalian telencephalon.
1997,
Pubmed Franz,
Extra-toes (Xt) homozygous mutant mice demonstrate a role for the Gli-3 gene in the development of the forebrain.
1994,
Pubmed Gotz,
Selective adhesion of cells from different telencephalic regions.
1996,
Pubmed Grove,
The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice.
1998,
Pubmed
,
Xenbase Haberly,
Structure of the piriform cortex of the opossum. I. Description of neuron types with Golgi methods.
1983,
Pubmed Hinds,
Early neuron differentiation in the mouse of olfactory bulb. I. Light microscopy.
1972,
Pubmed Hirata,
Environmental control of collateral branching and target invasion of mitral cell axons during development.
1999,
Pubmed Hui,
Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.
1994,
Pubmed Hui,
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.
1993,
Pubmed Inouye,
A bacterial cloning vector using a mutated Aequorea green fluorescent protein as an indicator.
1997,
Pubmed Johnson,
Extra-toes: anew mutant gene causing multiple abnormalities in the mouse.
1967,
Pubmed Kornack,
Radial and horizontal deployment of clonally related cells in the primate neocortex: relationship to distinct mitotic lineages.
1995,
Pubmed Levitt,
Patterning and specification of the cerebral cortex.
1997,
Pubmed Macdonald,
Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain.
1994,
Pubmed Mastick,
Initial organization of neurons and tracts in the embryonic mouse fore- and midbrain.
1996,
Pubmed Mastick,
Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain.
1997,
Pubmed Masuya,
A duplicated zone of polarizing activity in polydactylous mouse mutants.
1995,
Pubmed Matsunami,
Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion.
1995,
Pubmed Matsuo,
A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells.
1993,
Pubmed McConnell,
The control of neuronal identity in the developing cerebral cortex.
1992,
Pubmed McConnell,
Cell cycle dependence of laminar determination in developing neocortex.
1991,
Pubmed Mione,
Lineage analysis reveals neurotransmitter (GABA or glutamate) but not calcium-binding protein homogeneity in clonally related cortical neurons.
1994,
Pubmed Misson,
Identification of radial glial cells within the developing murine central nervous system: studies based upon a new immunohistochemical marker.
1988,
Pubmed Miyata,
Developmental Potentials of Early Telencephalic Neuroepithelial Cells: A Study with Microexplant Culture: (neurogenesis/commitment/neuroepithelium/telencephalon/culture).
1994,
Pubmed Naruse,
Induction of agenesis of the corpus callosum by the destruction of anlage of the olfactory bulb using fetal laser surgery exo utero in mice.
1993,
Pubmed Naruse,
Developmental brain abnormalities accompanied with the retarded production of S-100 beta protein in genetic polydactyly mice.
1990,
Pubmed Neyt,
A short-range signal restricts cell movement between telencephalic proliferative zones.
1997,
Pubmed Okabe,
'Green mice' as a source of ubiquitous green cells.
1997,
Pubmed O'Leary,
The specification of sensory cortex: lessons from cortical transplantation.
1992,
Pubmed O'Rourke,
Diverse migratory pathways in the developing cerebral cortex.
1992,
Pubmed Osumi-Yamashita,
The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos.
1994,
Pubmed Rakic,
Radial versus tangential migration of neuronal clones in the developing cerebral cortex.
1995,
Pubmed Rakic,
Specification of cerebral cortical areas.
1988,
Pubmed Rubenstein,
Patterning of the embryonic forebrain.
1998,
Pubmed Sakakibara,
Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell.
1996,
Pubmed
,
Xenbase Sasaki,
A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.
1997,
Pubmed
,
Xenbase Sato,
Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract.
1998,
Pubmed Schimmang,
Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt).
1992,
Pubmed Schlaggar,
Potential of visual cortex to develop an array of functional units unique to somatosensory cortex.
1991,
Pubmed Schwob,
The development of lamination of afferent fibers to the olfactory cortex in rats, with additional observations in the adult.
1984,
Pubmed Stanfield,
Fetal occipital cortical neurones transplanted to the rostral cortex can extend and maintain a pyramidal tract axon.
,
Pubmed Stoykova,
Forebrain patterning defects in Small eye mutant mice.
1996,
Pubmed Sugisaki,
Positional cues that are strictly localized in the telencephalon induce preferential growth of mitral cell axons.
1996,
Pubmed Tamamaki,
Origin and route of tangentially migrating neurons in the developing neocortical intermediate zone.
1997,
Pubmed Tan,
Separate progenitors for radial and tangential cell dispersion during development of the cerebral neocortex.
1998,
Pubmed Tan,
Radial mosaicism and tangential cell dispersion both contribute to mouse neocortical development.
1993,
Pubmed Tessier-Lavigne,
The molecular biology of axon guidance.
1996,
Pubmed Theil,
Gli3 is required for Emx gene expression during dorsal telencephalon development.
1999,
Pubmed
,
Xenbase Tole,
Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J).
2000,
Pubmed
,
Xenbase Walsh,
Widespread dispersion of neuronal clones across functional regions of the cerebral cortex.
1992,
Pubmed
