Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and slow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system.
Abrieu,
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
2001, Pubmed
Abrieu,
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
2001,
Pubmed Acar,
Enhancement of cellular memory by reducing stochastic transitions.
2005,
Pubmed Becskei,
Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion.
2001,
Pubmed Beltrami,
Mathematical analysis of activation thresholds in enzyme-catalyzed positive feedbacks: application to the feedbacks of blood coagulation.
1995,
Pubmed Berridge,
The versatility and complexity of calcium signalling.
2001,
Pubmed Bhalla,
MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network.
2002,
Pubmed Bornholdt,
Systems biology. Less is more in modeling large genetic networks.
2005,
Pubmed Butty,
A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.
2002,
Pubmed Cole,
Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO.
2004,
Pubmed Ferrell,
Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible.
2001,
Pubmed
,
Xenbase Gardner,
Construction of a genetic toggle switch in Escherichia coli.
2000,
Pubmed Harris,
The p53 pathway: positive and negative feedback loops.
2005,
Pubmed Hoffmann,
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.
1993,
Pubmed
,
Xenbase Holmsen,
Signal transducing mechanisms in platelets.
1991,
Pubmed Isaacs,
Prediction and measurement of an autoregulatory genetic module.
2003,
Pubmed Kaneko,
Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter.
2002,
Pubmed Laurent,
Multistability: a major means of differentiation and evolution in biological systems.
1999,
Pubmed Levine,
The CLN gene family: central regulators of cell cycle Start in budding yeast.
1995,
Pubmed Lewis,
Calcium signaling mechanisms in T lymphocytes.
2001,
Pubmed Margarit,
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.
2003,
Pubmed Medina,
Assembling a gene regulatory network for specification of the B cell fate.
2004,
Pubmed Reynolds,
EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation.
2003,
Pubmed Shvartsman,
Autocrine loops with positive feedback enable context-dependent cell signaling.
2002,
Pubmed Singh,
Contingent gene regulatory networks and B cell fate specification.
2005,
Pubmed Solomon,
Cyclin activation of p34cdc2.
1990,
Pubmed
,
Xenbase Thayer,
Positive autoregulation of the myogenic determination gene MyoD1.
1989,
Pubmed Wedlich-Soldner,
Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling.
2004,
Pubmed Wedlich-Soldner,
Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase.
2003,
Pubmed Weiner,
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.
2002,
Pubmed
