Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-12071
EMBO J 1999 Nov 01;1821:6062-72. doi: 10.1093/emboj/18.21.6062.
Show Gene links Show Anatomy links

The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer.

de Souza FS, Gawantka V, Gómez AP, Delius H, Ang SL, Niehrs C.


???displayArticle.abstract???
The anterior endomesoderm of the early Xenopus gastrula is a part of Spemann's organizer and is important for head induction. Here we describe Xblimp1, which encodes a zinc finger transcriptional repressor expressed in the anterior endomesoderm. Xblimp1 represses trunk mesoderm and induces anterior endomesoderm in a cooperative manner with the pan-endodermal gene Mix.1. Furthermore, Xblimp1 can cooperate with the BMP inhibitor chordin to induce ectopic heads, while a dominant-negative Xblimp1 inhibits head formation. The head inducer cerberus is positively regulated by Xblimp1 and is able to rescue microcephalic embryos caused by dominant-negative Xblimp1. Our results indicate that Xblimp1 is required for anterior endomesodermal cell fate and head induction.

???displayArticle.pubmedLink??? 10545117
???displayArticle.pmcLink??? PMC1171671
???displayArticle.link??? EMBO J


Species referenced: Xenopus
Genes referenced: cer1 chrd prdm1