Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Dev Biol
1999 Aug 15;2122:323-36. doi: 10.1006/dbio.1999.9335.
Show Gene links
Show Anatomy links
Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators.
Pearse RV, Collier LS, Scott MP, Tabin CJ.
???displayArticle.abstract???
The hedgehog (Hh) signaling pathway is crucial for pattern formation during metazoan development. Although originially characterized in Drosophila, vertebrate homologs have been identified for several, but not all, genes in the pathway. Analysis of mutants in Drosophila demonstrates that Suppressor of fused [Su(fu)] interacts genetically with genes encoding proteins in the Hh signal transduction pathway, and its protein product physically interacts with two of the proteins in the Hh pathway. We report here the molecular cloning and characterization of chicken and mouse homologs of Su(fu). The chick and mouse proteins are 27% identical and 53% similar at the amino acid level to the Drosophila melanogaster and Drosophila virilis proteins. Vertebrate Su(fu) is widely expressed in the developing embryo with higher levels in tissues that are known to be patterned by Hh signaling. The chick Su(fu) protein can physically interact with factors known to function in Hh signal transduction including the Drosophila serine/threonine kinase, Fused, and the vertebrate transcriptional regulators Gli1 and Gli3. This interaction may be significant for transcriptional regulation, as recombinant Su(fu) enhances the ability of Gli proteins to bind DNA in electrophoretic mobility shift assays.
Akiyama,
Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5.
1997, Pubmed
Akiyama,
Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5.
1997,
Pubmed Alcedo,
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.
1996,
Pubmed Alexandre,
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.
1996,
Pubmed Alves,
Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs.
1998,
Pubmed Aruga,
Identification and characterization of Zic4, a new member of the mouse Zic gene family.
1996,
Pubmed Aruga,
The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired.
1996,
Pubmed Aruga,
A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.
1994,
Pubmed Aza-Blanc,
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor.
1997,
Pubmed Bitgood,
Sertoli cell signaling by Desert hedgehog regulates the male germline.
1996,
Pubmed Bitgood,
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.
1995,
Pubmed Breeden,
Regulation of the yeast HO gene.
1985,
Pubmed Brewster,
Gli/Zic factors pattern the neural plate by defining domains of cell differentiation.
1998,
Pubmed
,
Xenbase Brown,
Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.
1998,
Pubmed Büscher,
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development.
1997,
Pubmed
,
Xenbase Carpenter,
Characterization of two patched receptors for the vertebrate hedgehog protein family.
1998,
Pubmed Chidambaram,
Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients.
1996,
Pubmed Dahmane,
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours.
1997,
Pubmed
,
Xenbase Dai,
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.
1999,
Pubmed
,
Xenbase Echelard,
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
1993,
Pubmed Fan,
Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog.
1997,
Pubmed Fietz,
The hedgehog gene family in Drosophila and vertebrate development.
1994,
Pubmed Gietz,
Improved method for high efficiency transformation of intact yeast cells.
1992,
Pubmed Goodrich,
Hedgehog and patched in neural development and disease.
1998,
Pubmed Goodrich,
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
1996,
Pubmed Grindley,
Evidence for the involvement of the Gli gene family in embryonic mouse lung development.
1997,
Pubmed
,
Xenbase Hahn,
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.
1996,
Pubmed Hamburger,
A series of normal stages in the development of the chick embryo. 1951.
1992,
Pubmed Hammerschmidt,
The world according to hedgehog.
1997,
Pubmed Hidalgo,
Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched.
1990,
Pubmed Hooper,
The Drosophila patched gene encodes a putative membrane protein required for segmental patterning.
1989,
Pubmed Hughes,
Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.
1997,
Pubmed
,
Xenbase Hui,
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.
1993,
Pubmed Hui,
Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.
1994,
Pubmed Ingham,
Transducing Hedgehog: the story so far.
1998,
Pubmed Ingham,
Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo.
1993,
Pubmed James,
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast.
1996,
Pubmed Kinzler,
Identification of an amplified, highly expressed gene in a human glioma.
1987,
Pubmed Kinzler,
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.
1990,
Pubmed Lee,
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.
1992,
Pubmed Lee,
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.
1997,
Pubmed
,
Xenbase Marigo,
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.
1996,
Pubmed
,
Xenbase Marigo,
Biochemical evidence that patched is the Hedgehog receptor.
1996,
Pubmed
,
Xenbase Marigo,
Regulation of patched by sonic hedgehog in the developing neural tube.
1996,
Pubmed Mo,
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.
1997,
Pubmed
,
Xenbase Monnier,
Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway.
1998,
Pubmed Motoyama,
Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog.
1998,
Pubmed Nagai,
The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation.
1997,
Pubmed Nakano,
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched.
1989,
Pubmed Nakata,
Xenopus Zic family and its role in neural and neural crest development.
1998,
Pubmed
,
Xenbase Nüsslein-Volhard,
Mutations affecting segment number and polarity in Drosophila.
1980,
Pubmed Ohlmeyer,
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.
,
Pubmed Orenic,
Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.
1990,
Pubmed
,
Xenbase Oro,
Basal cell carcinomas in mice overexpressing sonic hedgehog.
1997,
Pubmed Pham,
The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment.
1995,
Pubmed Préat,
Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2.
1993,
Pubmed Préat,
A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila.
1990,
Pubmed Préat,
Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster.
1992,
Pubmed Radhakrishna,
Mutation in GLI3 in postaxial polydactyly type A.
1997,
Pubmed
,
Xenbase Raffel,
Sporadic medulloblastomas contain PTCH mutations.
1997,
Pubmed Riddle,
Sonic hedgehog mediates the polarizing activity of the ZPA.
1993,
Pubmed Rimm,
New plasmid vectors for high level synthesis of eukaryotic fusion proteins in Escherichia coli.
1989,
Pubmed Robbins,
Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.
1997,
Pubmed Rogers,
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis.
1986,
Pubmed Ruppert,
GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.
1990,
Pubmed
,
Xenbase Schreiber,
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.
1989,
Pubmed Sisson,
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway.
1997,
Pubmed Stone,
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
1996,
Pubmed Tabata,
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs.
1994,
Pubmed Taylor,
Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo.
1993,
Pubmed Thérond,
Phosphorylation of the fused protein kinase in response to signaling from hedgehog.
1996,
Pubmed Unden,
Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.
1996,
Pubmed van den Heuvel,
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.
1996,
Pubmed Vorechovský,
Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis.
1997,
Pubmed Vortkamp,
GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families.
1991,
Pubmed
,
Xenbase Vortkamp,
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.
1996,
Pubmed Xie,
Activating Smoothened mutations in sporadic basal-cell carcinoma.
1998,
Pubmed
