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XB-ART-12647
Mech Dev 1999 Jul 01;851-2:97-102.
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A conserved 30 base pair element in the Wnt-5a promoter is sufficient both to drive its' early embryonic expression and to mediate its' repression by otx2.

Morgan R, Hooiveld MH, In der Reiden P, Durston AJ.


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We have characterised a short (30 base pair) element from the Xenopus Wnt-5a promoter which is nearly identical to one located in the human Wnt-5a promoter, and has the same position relative to the transcription start site. When placed in front of a LacZ gene, this element can reproduce the same expression pattern observed for Wnt-5a at the late gastrula stage. Further we show that gastrula stage Wnt-5a expression is repressed by otx2, something which is reflected by the mutually exclusive expression patterns of these two genes. The isolated promoter sequence contains an OTX- consensus binding site and its' activity in embryos is repressed by ectopically expressed otx2.

???displayArticle.pubmedLink??? 10415350
???displayArticle.link??? Mech Dev


Species referenced: Xenopus
Genes referenced: cnn1 muc2 otx2 wnt5a


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