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XB-ART-1390
J Recept Signal Transduct Res 2005 Jan 01;252:73-97. doi: 10.1081/rrs-200068115.
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Structural requirements for rapid inactivation and voltage dependence in splice variants of lobster Shaker potassium channels.

French LB, Singh A, Luik R, Harris-Warrick RM.


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We studied the properties of currents generated in Xenopus oocytes by nine splice variants of the spiny lobster Shaker gene. These isoforms differ in their amino termini and in the P-loop region of the pore. Both the voltage dependence and kinetic properties of the currents varied significantly, depending on which amino terminus was present. A cluster of net positive charges at the N-terminus was not necessary for rapid inactivation: negatively charged N-termini also inactivated rapidly. There was no obvious correlation between N-terminus length and inactivation rate. These N-terminal effects were additive with a separate set of voltage and kinetic properties controlled by the two alternative P-loop exons.

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???displayArticle.link??? J Recept Signal Transduct Res