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Proc Natl Acad Sci U S A
1998 Oct 27;9522:13056-61. doi: 10.1073/pnas.95.22.13056.
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Identification and characterization of amelogenin genes in monotremes, reptiles, and amphibians.
Toyosawa S, O'hUigin C, Figueroa F, Tichy H, Klein J.
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Two features make the tooth an excellent model in the study of evolutionary innovations: the relative simplicity of its structure and the fact that the major tooth-forming genes have been identified in eutherian mammals. To understand the nature of the innovation at the molecular level, it is necessary to identify the homologs of tooth-forming genes in other vertebrates. As a first step toward this goal, homologs of the eutherian amelogenin gene have been cloned and characterized in selected species of monotremes (platypus and echidna), reptiles (caiman), and amphibians (African clawed toad). Comparisons of the homologs reveal that the amelogenin gene evolves quickly in the repeat region, in which numerous insertions and deletions have obliterated any similarity among the genes, and slowly in other regions. The gene organization, the distribution of hydrophobic and hydrophilic segments in the encoded protein, and several other features have been conserved throughout the evolution of the tetrapod amelogenin gene. Clones corresponding to one locus only were found in caiman, whereas the clawed toad possesses at least two amelogenin-encoding loci.
Bailey,
The X-Y homologous gene amelogenin maps to the short arms of both the X and Y chromosomes and is highly conserved in primates.
1992, Pubmed
Bailey,
The X-Y homologous gene amelogenin maps to the short arms of both the X and Y chromosomes and is highly conserved in primates.
1992,
Pubmed Bonass,
Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence.
1994,
Pubmed Breathnach,
Organization and expression of eucaryotic split genes coding for proteins.
1981,
Pubmed Chirgwin,
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
1979,
Pubmed Deutsch,
Structure and function of enamel gene products.
1989,
Pubmed Fincham,
Amelogenin post-secretory processing during biomineralization in the postnatal mouse molar tooth.
1991,
Pubmed Fincham,
Amelogenin proteins of developing dental enamel.
1997,
Pubmed Gibson,
Structure and expression of the bovine amelogenin gene.
1991,
Pubmed Gibson,
Bovine amelogenin message heterogeneity: alternative splicing and Y-chromosomal gene transcription.
1992,
Pubmed Herold,
Phylogenetic distribution of enamel proteins: immunohistochemical localization with monoclonal antibodies indicates the evolutionary appearance of enamelins prior to amelogenins.
1989,
Pubmed Hu,
Cloning, DNA sequence, and alternative splicing of opossum amelogenin mRNAs.
1996,
Pubmed Hu,
Cloning, cDNA sequence, and alternative splicing of porcine amelogenin mRNAs.
1996,
Pubmed Ito,
Prediction of protein secondary structure using the 3D-1D compatibility algorithm.
1997,
Pubmed Kumar,
A molecular timescale for vertebrate evolution.
1998,
Pubmed Kyte,
A simple method for displaying the hydropathic character of a protein.
1982,
Pubmed Lagerström,
Mapping of the gene for X-linked amelogenesis imperfecta by linkage analysis.
1990,
Pubmed Lau,
Human and mouse amelogenin gene loci are on the sex chromosomes.
1989,
Pubmed Lau,
Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity.
1992,
Pubmed Li,
Alternative splicing of amelogenin mRNA from rat incisor ameloblasts.
1995,
Pubmed Li,
A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes.
1985,
Pubmed Nakahori,
A human X-Y homologous region encodes "amelogenin".
1991,
Pubmed O'hUigin,
The molecular clock ticks regularly in muroid rodents and hamsters.
1992,
Pubmed Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed Salido,
The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes.
1992,
Pubmed Shimokawa,
Heterogeneity of amelogenin mRNA in the bovine tooth germ.
1987,
Pubmed Watson,
Autosomal localization of the amelogenin gene in monotremes and marsupials: implications for mammalian sex chromosome evolution.
1992,
Pubmed Yen,
The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution.
1988,
Pubmed
