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XB-ART-14288
Kidney Int Suppl 1998 Sep 01;67:S109-14. doi: 10.1046/j.1523-1755.1998.06721.x.
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Epithelial sodium channel regulatory proteins identified by functional expression cloning.

Vallet V, Horisberger JD, Rossier BC.


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We describe here our current strategy for identifying and cloning proteins involved in the regulation of the epithelial sodium channel (ENaC). We have set up a complementation functional assay in the Xenopus laevis oocyte expression system. Using this assay, we have been able to identify a channel-activating protease (CAP-1) that can increase ENaC activity threefold. We propose a novel extracellular signal transduction pathway controlling ionic channels of the ENaC gene family that include genes involved in mechanotransduction (degenerins), in peptide-gated channels involved in neurotransmission (FaNaCh), in proton-gated channels involved in pH sensing (ASIC) or pain sensation (DRASIC).

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Species referenced: Xenopus laevis
Genes referenced: asic1 asic3