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EMBO J
1998 Jun 15;1712:3297-308. doi: 10.1093/emboj/17.12.3297.
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A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.
Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M.
???displayArticle.abstract??? TWIK-1, TREK-1 and TASK K+ channels comprise a class of pore-forming subunits with four membrane-spanning segments and two P domains. Here we report the cloning of TRAAK, a 398 amino acid protein which is a new member of this mammalian class of K+ channels. Unlike TWIK-1, TREK-1 and TASK which are widely distributed in many different mouse tissues, TRAAK is present exclusively in brain, spinal cord and retina. Expression of TRAAK in Xenopus oocytes and COS cells induces instantaneous and non-inactivating currents that are not gated by voltage. These currents are only partially inhibited by Ba2+ at high concentrations and are insensitive to the other classical K+ channel blockers tetraethylammonium, 4-aminopyridine and Cs+. A particularly salient feature of TRAAK is that they can be stimulated by arachidonic acid (AA) and other unsaturated fatty acids but not by saturated fatty acids. These channels probably correspond to the functional class of fatty acid-stimulated K+ currents that recently were identified in native neuronal cells but have not yet been cloned. These TRAAK channels might be essential in normal physiological processes in which AA is known to play an important role, such as synaptic transmission, and also in pathophysiological processes such as brain ischemia. TRAAK channels are stimulated by the neuroprotective drug riluzole.
Altschul,
Basic local alignment search tool.
1990, Pubmed
Altschul,
Basic local alignment search tool.
1990,
Pubmed Backx,
Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes.
1993,
Pubmed Barhanin,
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current.
1996,
Pubmed
,
Xenbase Barnard,
The transmitter-gated channels: a range of receptor types and structures.
1996,
Pubmed Bazan,
Arachidonic acid in the modulation of excitable membrane function and at the onset of brain damage.
1989,
Pubmed Bensimon,
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.
1994,
Pubmed Bliss,
A synaptic model of memory: long-term potentiation in the hippocampus.
1993,
Pubmed Bryson,
Riluzole. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis.
1996,
Pubmed Buckler,
A novel oxygen-sensitive potassium current in rat carotid body type I cells.
1997,
Pubmed Burton,
Accumulation of arachidonate in triacylglycerols and unesterified fatty acids during ischemia and reflow in the isolated rat heart. Correlation with the loss of contractile function and the development of calcium overload.
1986,
Pubmed Calabresi,
Long-term synaptic depression in the striatum: physiological and pharmacological characterization.
1992,
Pubmed Chan,
The role of arachidonic acid and oxygen radical metabolites in the pathogenesis of vasogenic brain edema and astrocytic swelling.
1989,
Pubmed Czempinski,
New structure and function in plant K+ channels: KCO1, an outward rectifier with a steep Ca2+ dependency.
1997,
Pubmed Duprat,
TASK, a human background K+ channel to sense external pH variations near physiological pH.
1997,
Pubmed
,
Xenbase Enyeart,
Adrenocorticotropic hormone and cAMP inhibit noninactivating K+ current in adrenocortical cells by an A-kinase-independent mechanism requiring ATP hydrolysis.
1996,
Pubmed Fink,
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.
1996,
Pubmed
,
Xenbase Glowatzki,
Subunit-dependent assembly of inward-rectifier K+ channels.
1995,
Pubmed
,
Xenbase Goldstein,
ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae.
1996,
Pubmed
,
Xenbase Guillemare,
Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2.
1992,
Pubmed
,
Xenbase Hansen,
Effect of anoxia on ion distribution in the brain.
1985,
Pubmed Hartmann,
Exchange of conduction pathways between two related K+ channels.
1991,
Pubmed
,
Xenbase Heginbotham,
Mutations in the K+ channel signature sequence.
1994,
Pubmed
,
Xenbase Heurteaux,
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.
1993,
Pubmed Honoré,
External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids.
1994,
Pubmed Inagaki,
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
1995,
Pubmed Isacoff,
Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes.
1990,
Pubmed
,
Xenbase Isomoto,
Inwardly rectifying potassium channels: their molecular heterogeneity and function.
1997,
Pubmed
,
Xenbase Jan,
Potassium channels and their evolving gates.
1994,
Pubmed Jurman,
Visual identification of individual transfected cells for electrophysiology using antibody-coated beads.
1994,
Pubmed Kandel,
Are adult learning mechanisms also used for development?
1992,
Pubmed Kemp,
Protein kinase recognition sequence motifs.
1990,
Pubmed Keros,
Arachidonic acid inhibits transient potassium currents and broadens action potentials during electrographic seizures in hippocampal pyramidal and inhibitory interneurons.
1997,
Pubmed Kim,
Arachidonic acid activation of a new family of K+ channels in cultured rat neuronal cells.
1995,
Pubmed Koh,
A TEA-insensitive flickering potassium channel active around the resting potential in myelinated nerve.
1992,
Pubmed
,
Xenbase Koyano,
A patch-clamp study on the muscarine-sensitive potassium channel in bullfrog sympathetic ganglion cells.
1992,
Pubmed Kyte,
A simple method for displaying the hydropathic character of a protein.
1982,
Pubmed Leonoudakis,
An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum.
1998,
Pubmed
,
Xenbase Lesage,
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
1996,
Pubmed
,
Xenbase Lesage,
The structure, function and distribution of the mouse TWIK-1 K+ channel.
1997,
Pubmed
,
Xenbase Lesage,
Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge.
1996,
Pubmed
,
Xenbase Lingueglia,
Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins.
1993,
Pubmed
,
Xenbase MacKinnon,
Pore loops: an emerging theme in ion channel structure.
1995,
Pubmed Malgouris,
Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils.
1989,
Pubmed Meves,
Modulation of ion channels by arachidonic acid.
1994,
Pubmed Nichols,
Inward rectifier potassium channels.
1997,
Pubmed Pellegrini,
Two types of K+ channels in excised patches of somatic membrane of the leech AP neuron.
1989,
Pubmed Piomelli,
Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells.
,
Pubmed Piomelli,
Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism.
1991,
Pubmed Pongs,
Molecular biology of voltage-dependent potassium channels.
1992,
Pubmed Pratt,
Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia.
1992,
Pubmed Premkumar,
GABA-induced potassium channels in cultured neurons.
1990,
Pubmed Premkumar,
Coupled potassium channels induced by arachidonic acid in cultured neurons.
1990,
Pubmed Quast,
Potassium channel openers: pharmacological and clinical aspects.
1992,
Pubmed Romettino,
Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy.
1991,
Pubmed Rudy,
Diversity and ubiquity of K channels.
1988,
Pubmed Ruppersberg,
Heteromultimeric channels formed by rat brain potassium-channel proteins.
1990,
Pubmed
,
Xenbase Shen,
Potassium channels opened by noradrenaline and other transmitters in excised membrane patches of guinea-pig submucosal neurones.
1992,
Pubmed Siegelbaum,
Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones.
1982,
Pubmed Siesjö,
Arachidonic acid metabolism in seizures.
1989,
Pubmed Stutzmann,
Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat.
1991,
Pubmed Theander,
Analysis of leak current properties in the lobster stretch receptor neurone.
1996,
Pubmed Villarroel,
Inhibition of the Kv4 (Shal) family of transient K+ currents by arachidonic acid.
1996,
Pubmed Villarroel,
Suppression of neuronal potassium A-current by arachidonic acid.
1993,
Pubmed Wagner,
cAMP modulates an S-type K+ channel coupled to GABAB receptors in mammalian respiratory neurons.
1997,
Pubmed Wu,
Single channel characterization of multiple types of potassium channels in demyelinated Xenopus axons.
1993,
Pubmed
,
Xenbase Yang,
Determination of the subunit stoichiometry of an inwardly rectifying potassium channel.
1995,
Pubmed
,
Xenbase Yool,
Alteration of ionic selectivity of a K+ channel by mutation of the H5 region.
1991,
Pubmed
,
Xenbase Yue,
A novel cardiac potassium channel that is active and conductive at depolarized potentials.
1988,
Pubmed
