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Identification of two nervous system-specific members of the erg potassium channel gene family.
Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D, Dixon JE.
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Two new potassium channel genes, erg2 and erg3, that are expressed in the nervous system of the rat were identified. These two genes form a small gene family with the previously described erg1 (HERG) gene. The erg2 and erg3 genes are expressed exclusively in the nervous system, in marked contrast to erg1, which is expressed in both neural and non-neural tissues. All three genes are expressed in peripheral sympathetic ganglia. The erg3 channel produces a current that has a large transient component at positive potentials, whereas the other two channels are slowly activating delayed rectifiers. Expression of the erg1 gene in the sympathetic nervous system has potential implications for the etiology of the LQT2 form of the human genetic disease long QT syndrome.
Barhanin,
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current.
1996, Pubmed,
Xenbase
Barhanin,
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current.
1996,
Pubmed
,
Xenbase Brown,
M currents.
1988,
Pubmed Cassell,
Characteristics of phasic and tonic sympathetic ganglion cells of the guinea-pig.
1986,
Pubmed Chiesa,
A novel role for HERG K+ channels: spike-frequency adaptation.
1997,
Pubmed Curran,
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.
1995,
Pubmed Dixon,
Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats.
1994,
Pubmed Dixon,
Potassium channel mRNA expression in prevertebral and paravertebral sympathetic neurons.
1996,
Pubmed Faravelli,
A HERG-like K+ channel in rat F-11 DRG cell line: pharmacological identification and biophysical characterization.
1996,
Pubmed Frohman,
On beyond classic RACE (rapid amplification of cDNA ends).
1994,
Pubmed Ganetzky,
Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants.
1983,
Pubmed Gellens,
Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.
1992,
Pubmed
,
Xenbase Ludwig,
Functional expression of a rat homologue of the voltage gated either á go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart.
1994,
Pubmed
,
Xenbase Roden,
Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS.
1996,
Pubmed Sanguinetti,
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel.
1995,
Pubmed
,
Xenbase Sanguinetti,
Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.
1996,
Pubmed
,
Xenbase Sanguinetti,
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.
1996,
Pubmed
,
Xenbase Sanguinetti,
Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.
1990,
Pubmed Shibasaki,
Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart.
1987,
Pubmed Smith,
The inward rectification mechanism of the HERG cardiac potassium channel.
1996,
Pubmed Snyders,
High affinity open channel block by dofetilide of HERG expressed in a human cell line.
1996,
Pubmed
,
Xenbase Spector,
Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides.
1996,
Pubmed
,
Xenbase Terlau,
Extracellular Mg2+ regulates activation of rat eag potassium channel.
1996,
Pubmed
,
Xenbase Thompson,
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
1994,
Pubmed Titus,
The Drosophila erg K+ channel polypeptide is encoded by the seizure locus.
1997,
Pubmed Trudeau,
HERG, a human inward rectifier in the voltage-gated potassium channel family.
1995,
Pubmed Wang,
SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome.
1995,
Pubmed Wang,
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.
1996,
Pubmed Wang,
The seizure locus encodes the Drosophila homolog of the HERG potassium channel.
1997,
Pubmed Wang,
Potassium currents in rat prevertebral and paravertebral sympathetic neurones: control of firing properties.
1995,
Pubmed Wang,
Modulation of inwardly rectifying currents in rat sympathetic neurones by muscarinic receptors.
1996,
Pubmed Warmke,
A distinct potassium channel polypeptide encoded by the Drosophila eag locus.
1991,
Pubmed Warmke,
A family of potassium channel genes related to eag in Drosophila and mammals.
1994,
Pubmed Wymore,
Tissue and species distribution of mRNA for the IKr-like K+ channel, erg.
1997,
Pubmed
,
Xenbase
