Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos.
Kaufmann E, Paul H, Friedle H, Metz A, Scheucher M, Clement JH, Knöchel W.
???displayArticle.abstract???
Transcription of the early response gene XFD-1' (XFKH1) in the dorsal lip (Spemann organizer) of Xenopus embryos is activated by dorsal mesoderm inducing factors. Promoter studies revealed the presence of an activin A response element (ARE) which is both necessary and sufficient for transcriptional activation of reporter genes in animal cap explants incubated with activin A. Surprisingly, this ARE is also active within vegetal explants in the absence of exogenously added inducers, but an additional inhibitory response element prevents transcription of the XFD-1' gene in the ventral/vegetal region of the embryo in vivo. This element is located upstream of the ARE, it responds to bone morphogenic proteins 2 and 4 (BMP-2/4) triggered signals and it overrides the activating properties of the ARE. Expression patterns of BMP-2 and BMP-4 in the late blastula stage embryo and, especially, their absence from the dorsal blastopore lip may thus control the spatial transcription of the XFD-1' gene. Accordingly, the temporal activation and the spatial restriction of XFD-1' gene activity to the Spemann organizer is regulated by antagonistic actions of two distinct members of the TGF-beta family (activin and BMP) which act on different promoter elements.
Ang,
HNF-3 beta is essential for node and notochord formation in mouse development.
1994, Pubmed
Ang,
HNF-3 beta is essential for node and notochord formation in mouse development.
1994,
Pubmed Cho,
Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid.
1991,
Pubmed
,
Xenbase Clement,
Bone morphogenetic protein 2 in the early development of Xenopus laevis.
1995,
Pubmed
,
Xenbase Cornell,
Activin-mediated mesoderm induction requires FGF.
1994,
Pubmed
,
Xenbase Dale,
Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development.
1992,
Pubmed
,
Xenbase Dale,
Regional specification within the mesoderm of early embryos of Xenopus laevis.
1987,
Pubmed
,
Xenbase Dawid,
Intercellular signaling and gene regulation during early embryogenesis of Xenopus laevis.
1994,
Pubmed
,
Xenbase Detrick,
The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos.
1990,
Pubmed
,
Xenbase Dirksen,
A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.
1992,
Pubmed
,
Xenbase Fainsod,
On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.
1994,
Pubmed
,
Xenbase Gorman,
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
1982,
Pubmed Graff,
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo.
1994,
Pubmed
,
Xenbase Graff,
Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.
1996,
Pubmed
,
Xenbase Harland,
In situ hybridization: an improved whole-mount method for Xenopus embryos.
1991,
Pubmed
,
Xenbase Hawley,
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.
1995,
Pubmed
,
Xenbase Hemmati-Brivanlou,
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity.
1994,
Pubmed
,
Xenbase Hoodless,
MADR1, a MAD-related protein that functions in BMP2 signaling pathways.
1996,
Pubmed Huang,
Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.
1995,
Pubmed
,
Xenbase Jones,
Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos.
1996,
Pubmed
,
Xenbase Jones,
DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
1992,
Pubmed
,
Xenbase Joore,
Regulation of the zebrafish goosecoid promoter by mesoderm inducing factors and Xwnt1.
1996,
Pubmed Kaufmann,
Five years on the wings of fork head.
1996,
Pubmed Kessler,
Vertebrate embryonic induction: mesodermal and neural patterning.
1994,
Pubmed
,
Xenbase Knöchel,
Activin A induced expression of a fork head related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos.
1992,
Pubmed
,
Xenbase Köster,
Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity.
1991,
Pubmed
,
Xenbase Kothary,
Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice.
1989,
Pubmed LaBonne,
Mesoderm induction by activin requires FGF-mediated intracellular signals.
1994,
Pubmed
,
Xenbase Lamb,
Neural induction by the secreted polypeptide noggin.
1993,
Pubmed
,
Xenbase Liu,
A human Mad protein acting as a BMP-regulated transcriptional activator.
1996,
Pubmed
,
Xenbase Loreni,
Nucleotide sequence of the L1 ribosomal protein gene of Xenopus laevis: remarkable sequence homology among introns.
1985,
Pubmed
,
Xenbase Maéno,
A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of ventral mesoderm.
1994,
Pubmed
,
Xenbase Mayor,
Distinct elements of the xsna promoter are required for mesodermal and ectodermal expression.
1993,
Pubmed
,
Xenbase Moos,
Anti-dorsalizing morphogenetic protein is a novel TGF-beta homolog expressed in the Spemann organizer.
1995,
Pubmed
,
Xenbase Nishimatsu,
Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos.
1992,
Pubmed
,
Xenbase Northrop,
BMP-4 regulates the dorsal-ventral differences in FGF/MAPKK-mediated mesoderm induction in Xenopus.
1995,
Pubmed
,
Xenbase Ovsenek,
A maternal factor, OZ-1, activates embryonic transcription of the Xenopus laevis GS17 gene.
1992,
Pubmed
,
Xenbase Pani,
Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein.
1992,
Pubmed Re'em-Kalma,
Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.
1995,
Pubmed
,
Xenbase Ruiz i Altaba,
Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis.
1992,
Pubmed
,
Xenbase Sasai,
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus.
1995,
Pubmed
,
Xenbase Sasai,
Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes.
1994,
Pubmed
,
Xenbase Schubiger,
The Vi element. A transposon-like repeated DNA sequence interspersed in the vitellogenin locus of Xenopus laevis.
1985,
Pubmed
,
Xenbase Shawlot,
Requirement for Lim1 in head-organizer function.
1995,
Pubmed Shoda,
Presence of high molecular weight forms of BMP-2 in early Xenopus embryos.
1993,
Pubmed
,
Xenbase Slack,
Inducing factors in Xenopus early embryos.
1994,
Pubmed
,
Xenbase Smith,
A nodal-related gene defines a physical and functional domain within the Spemann organizer.
1995,
Pubmed
,
Xenbase Smith,
Dorsalization and neural induction: properties of the organizer in Xenopus laevis.
1983,
Pubmed
,
Xenbase Smith,
Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm.
1993,
Pubmed
,
Xenbase Suzuki,
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.
1994,
Pubmed
,
Xenbase Tadano,
Differential induction of regulatory genes during mesoderm formation in Xenopus laevis embryos.
1993,
Pubmed
,
Xenbase Taira,
The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos.
1992,
Pubmed
,
Xenbase Thomsen,
Processed Vg1 protein is an axial mesoderm inducer in Xenopus.
1993,
Pubmed
,
Xenbase Ueno,
Identification of bone morphogenetic protein-2 in early Xenopus laevis embryos.
1992,
Pubmed
,
Xenbase Watabe,
Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.
1995,
Pubmed
,
Xenbase Weber,
Mesoderm and endoderm differentiation in animal cap explants: identification of the HNF4-binding site as an activin A responsive element in the Xenopus HNF1alpha promoter.
1996,
Pubmed
,
Xenbase Weinstein,
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.
1994,
Pubmed Wilson,
Induction of epidermis and inhibition of neural fate by Bmp-4.
1995,
Pubmed
,
Xenbase Xu,
A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm.
1995,
Pubmed
,
Xenbase Xu,
Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopus embryonic development.
1996,
Pubmed
,
Xenbase Yamaguchi,
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.
1995,
Pubmed Zapp,
Elements and factors involved in tissue-specific and embryonic expression of the liver transcription factor LFB1 in Xenopus laevis.
1993,
Pubmed
,
Xenbase
