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Proc Natl Acad Sci U S A
1996 Nov 12;9323:13362-6. doi: 10.1073/pnas.93.23.13362.
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Heteromultimeric CLC chloride channels with novel properties.
Lorenz C, Pusch M, Jentsch TJ.
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The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.
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