Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1996 Nov 12;9323:13256-61. doi: 10.1073/pnas.93.23.13256.
Show Gene links
Show Anatomy links
ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae.
Goldstein SA, Price LA, Rosenthal DN, Pausch MH.
???displayArticle.abstract???
A K+ channel gene has been cloned from Drosophila melanogaster by complementation in Saccharomyces cerevisiae cells defective for K+ uptake. Naturally expressed in the neuromuscular tissues of adult flies, this gene confers K+ transport capacity on yeast cells when heterologously expressed. In Xenopus laevis oocytes, expression yields an ungated K(+)-selective current whose attributes resemble the "leak" conductance thought to mediate the resting potential of vertebrate myelinated neurons but whose molecular nature has long remained elusive. The predicted protein has two pore (P) domains and four membrane-spanning helices and is a member of a newly recognized K+ channel family. Expression of the channel in flies and yeast cells makes feasible studies of structure and in vivo function using genetic approaches that are not possible in higher animals.
Anderson,
Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae.
1992, Pubmed
Anderson,
Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae.
1992,
Pubmed Atkinson,
A component of calcium-activated potassium channels encoded by the Drosophila slo locus.
1991,
Pubmed Baker,
Function and distribution of three types of rectifying channel in rat spinal root myelinated axons.
1987,
Pubmed Baukrowitz,
Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms.
1995,
Pubmed Bennetzen,
The primary structure of the Saccharomyces cerevisiae gene for alcohol dehydrogenase.
1982,
Pubmed Brüggemann,
Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP.
1993,
Pubmed
,
Xenbase Butler,
A family of putative potassium channel genes in Drosophila.
1989,
Pubmed Campbell,
Kinetic and pharmacological properties of the sodium channel of frog skeletal muscle.
1976,
Pubmed Carmeliet,
K+ channels in cardiac cells: mechanisms of activation, inactivation, rectification and K+e sensitivity.
1989,
Pubmed Cavener,
Eukaryotic start and stop translation sites.
1991,
Pubmed Chiu,
A quantitative description of membrane currents in rabbit myelinated nerve.
1979,
Pubmed Coronado,
Conduction and block by organic cations in a K+-selective channel from sarcoplasmic reticulum incorporated into planar phospholipid bilayers.
1982,
Pubmed Elledge,
Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.
1991,
Pubmed Fakler,
Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine.
1995,
Pubmed
,
Xenbase Fozzard,
The electrophysiology of acute myocardial ischemia.
1985,
Pubmed FRANKENHAEUSER,
The after-effects of impulses in the giant nerve fibres of Loligo.
1956,
Pubmed FRANKENHAEUSER,
A QUANTITATIVE DESCRIPTION OF POTASSIUM CURRENTS IN MYELINATED NERVE FIBRES OF XENOPUS LAEVIS.
1963,
Pubmed
,
Xenbase Glowatzki,
Subunit-dependent assembly of inward-rectifier K+ channels.
1995,
Pubmed
,
Xenbase Goldman,
POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES.
1943,
Pubmed Heginbotham,
Mutations in the K+ channel signature sequence.
1994,
Pubmed
,
Xenbase Heinemann,
Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue.
1986,
Pubmed HODGKIN,
A quantitative description of membrane current and its application to conduction and excitation in nerve.
1952,
Pubmed HODGKIN,
The effect of sodium ions on the electrical activity of giant axon of the squid.
1949,
Pubmed Jan,
Potassium channels and their evolving gates.
1994,
Pubmed Kamb,
Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel.
1987,
Pubmed Ketchum,
A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.
1995,
Pubmed
,
Xenbase Knoll,
The early evolution of eukaryotes: a geological perspective.
1992,
Pubmed Ko,
TRK1 and TRK2 encode structurally related K+ transporters in Saccharomyces cerevisiae.
1991,
Pubmed Kozak,
An analysis of vertebrate mRNA sequences: intimations of translational control.
1991,
Pubmed Krapivinsky,
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.
1995,
Pubmed
,
Xenbase Kubo,
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
1993,
Pubmed
,
Xenbase Lesage,
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
1996,
Pubmed
,
Xenbase Lopatin,
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification.
1994,
Pubmed
,
Xenbase López-Barneo,
Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels.
1993,
Pubmed
,
Xenbase Loughney,
Molecular analysis of the para locus, a sodium channel gene in Drosophila.
1989,
Pubmed Lu,
Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel.
1994,
Pubmed
,
Xenbase MacKinnon,
Pore loops: an emerging theme in ion channel structure.
1995,
Pubmed MacKinnon,
Determination of the subunit stoichiometry of a voltage-activated potassium channel.
1991,
Pubmed
,
Xenbase Manley,
Polyadenylation of mRNA precursors.
1988,
Pubmed Needleman,
A general method applicable to the search for similarities in the amino acid sequence of two proteins.
1970,
Pubmed Neyton,
Discrete Ba2+ block as a probe of ion occupancy and pore structure in the high-conductance Ca2+ -activated K+ channel.
1988,
Pubmed Papazian,
Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.
1987,
Pubmed Pardo,
Extracellular K+ specifically modulates a rat brain K+ channel.
1992,
Pubmed
,
Xenbase Pongs,
Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.
1988,
Pubmed RITCHIE,
The hyperpolarization which follows activity in mammalian non-medullated fibres.
1957,
Pubmed Salkoff,
Surfing the DNA databases for K+ channels nets yet more diversity.
1995,
Pubmed Schachtman,
Structure and transport mechanism of a high-affinity potassium uptake transporter from higher plants.
1994,
Pubmed
,
Xenbase Sentenac,
Cloning and expression in yeast of a plant potassium ion transport system.
1992,
Pubmed Shapiro,
Permeant ion effects on the gating kinetics of the type L potassium channel in mouse lymphocytes.
1991,
Pubmed Silver,
Effects of external Rb+ on inward rectifier K+ channels of bovine pulmonary artery endothelial cells.
1994,
Pubmed Strong,
Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability.
1993,
Pubmed Swenson,
K+ channels close more slowly in the presence of external K+ and Rb+.
1981,
Pubmed Vandenberg,
Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions.
1987,
Pubmed Wang,
Subunit composition of minK potassium channels.
1995,
Pubmed
,
Xenbase Wang,
MinK residues line a potassium channel pore.
1996,
Pubmed Wei,
K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.
1990,
Pubmed
,
Xenbase Wilson,
2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.
1994,
Pubmed Woodhull,
Ionic blockage of sodium channels in nerve.
1973,
Pubmed Yang,
Determination of the subunit stoichiometry of an inwardly rectifying potassium channel.
1995,
Pubmed
,
Xenbase Yasuda,
Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.
1992,
Pubmed Zhou,
YKC1 encodes the depolarization-activated K+ channel in the plasma membrane of yeast.
1995,
Pubmed
