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We have identified two new genes, neuroD2 and neuroD3, on the basis of their similarity to the neurogenic basic-helix-loop-helix (bHLH) gene neuroD. The predicted amino acid sequence of neuroD2 shows a high degree of homology to neuroD and MATH-2/NEX-1 in the bHLH region, whereas neuroD3 is a more distantly related family member. neuroD3 is expressed transiently during embryonic development, with the highest levels of expression between days 10 and 12. neuroD2 is initially expressed at embryonic day 11, with persistent expression in the adult nervous system. In situ and Northern (RNA) analyses demonstrate that different regions of the adult nervous system have different relative amounts of neuroD and neuroD2 RNA. Similar to neuroD, expression of neuroD2 in developing Xenopus laevis embryos results in ectopic neurogenesis, indicating that neuroD2 mediates neuronal differentiation. Transfection of vectors expressing neuroD and neuroD2 into P19 cells shows that both can activate expression through simple E-box-driven reporter constructs and can activate a reporter driven by the neuroD2 promoter region, but the GAP-43 promoter is preferentially activated by neuroD2. The noncongruent expression pattern and target gene specificity of these highly related neurogenic bHLH proteins make them candidates for conferring specific aspects of the neuronal phenotype.
Akazawa,
A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system.
1995, Pubmed
Akazawa,
A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system.
1995,
Pubmed Anderson,
Neural development. Spinning skin into neurons.
1995,
Pubmed
,
Xenbase Asakura,
MyoD and myogenin act on the chicken myosin light-chain 1 gene as distinct transcriptional factors.
1993,
Pubmed Asakura,
The regulation of MyoD gene expression: conserved elements mediate expression in embryonic axial muscle.
1995,
Pubmed
,
Xenbase Balak,
Neural cell adhesion molecule expression in Xenopus embryos.
1987,
Pubmed
,
Xenbase Bartholomä,
NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons.
1994,
Pubmed Burgess,
Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites.
1995,
Pubmed Campuzano,
Patterning of the Drosophila nervous system: the achaete-scute gene complex.
1992,
Pubmed Cross,
Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development.
1995,
Pubmed Cserjesi,
Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis.
1995,
Pubmed Davis,
Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12.
1992,
Pubmed Davis,
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation.
1990,
Pubmed Hasty,
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene.
1993,
Pubmed Hollenberg,
Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system.
1995,
Pubmed Hughes,
Selective accumulation of MyoD and myogenin mRNAs in fast and slow adult skeletal muscle is controlled by innervation and hormones.
1993,
Pubmed Jarman,
atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system.
1993,
Pubmed Jones-Villeneuve,
Retinoic acid-induced neural differentiation of embryonal carcinoma cells.
1983,
Pubmed Krieg,
In vitro RNA synthesis with SP6 RNA polymerase.
1987,
Pubmed Kume,
Molecular cloning of a novel basic helix-loop-helix protein from the rat brain.
1996,
Pubmed Lee,
Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein.
1995,
Pubmed
,
Xenbase Lo,
Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells.
1991,
Pubmed Masters,
Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles.
1994,
Pubmed Nabeshima,
Myogenin gene disruption results in perinatal lethality because of severe muscle defect.
1993,
Pubmed Naya,
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.
1995,
Pubmed Nedivi,
A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity.
1992,
Pubmed Rudnicki,
MyoD or Myf-5 is required for the formation of skeletal muscle.
1993,
Pubmed Shen,
B-cell-specific DNA binding by an E47 homodimer.
1995,
Pubmed Shimizu,
MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system.
1995,
Pubmed Tamimi,
The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2.
1996,
Pubmed Tamura,
Identification of a DNA sequence involved in osteoblast-specific gene expression via interaction with helix-loop-helix (HLH)-type transcription factors.
1994,
Pubmed Tapscott,
Deficiency in rhabdomyosarcomas of a factor required for MyoD activity and myogenesis.
1993,
Pubmed Tassabehji,
Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene.
1994,
Pubmed Turner,
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
1994,
Pubmed
,
Xenbase Venuti,
Myogenin is required for late but not early aspects of myogenesis during mouse development.
1995,
Pubmed Weintraub,
MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.
1990,
Pubmed Weintraub,
The MyoD family and myogenesis: redundancy, networks, and thresholds.
1993,
Pubmed Weintraub,
Muscle-specific transcriptional activation by MyoD.
1991,
Pubmed Weintraub,
The myoD gene family: nodal point during specification of the muscle cell lineage.
1991,
Pubmed Yasunami,
Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1.
1996,
Pubmed Zhuang,
The helix-loop-helix gene E2A is required for B cell formation.
1994,
Pubmed
