Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1996 Jul 23;9315:8083-8. doi: 10.1073/pnas.93.15.8083.
Show Gene links
Show Anatomy links
Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator.
???displayArticle.abstract???
We demonstrate here that coexpression of ROMK2, an inwardly rectifying ATP-sensitive renal K+ channel (IKATP) with cystic fibrosis transmembrane regulator (CFTR) significantly enhances the sensitivity of ROMK2 to the sulfonylurea compound glibenclamide. When expressed alone, ROMK2 is relatively insensitive to glibenclamide. The interaction between ROMK2, CFTR, and glibenclamide is modulated by altering the phosphorylation state of either ROMK2, CFTR, or an associated protein, as exogenous MgATP and the catalytic subunit of protein kinase A significantly attenuate the inhibitory effect of glibenclamide on ROMK2. Thus CFTR, which has been demonstrated to interact with both Na+ and Cl- channels in airway epithelium, modulates the function of renal ROMK2 K+ channels.
Aguilar-Bryan,
Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.
1995, Pubmed
Aguilar-Bryan,
Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.
1995,
Pubmed Barasch,
Defective acidification of intracellular organelles in cystic fibrosis.
1991,
Pubmed Boim,
ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and distribution of alternative forms.
1995,
Pubmed
,
Xenbase Bradbury,
Regulated endocytosis in a chloride secretory epithelial cell line.
1992,
Pubmed Canessa,
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits.
1994,
Pubmed
,
Xenbase Crawford,
Immunocytochemical localization of the cystic fibrosis gene product CFTR.
1991,
Pubmed Dascal,
Atrial G protein-activated K+ channel: expression cloning and molecular properties.
1993,
Pubmed
,
Xenbase Edwards,
The pharmacology of ATP-sensitive potassium channels.
1993,
Pubmed Egan,
Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR.
1992,
Pubmed Gabriel,
CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship.
1993,
Pubmed Gill,
Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein.
1992,
Pubmed Higgins,
The ABC of channel regulation.
1995,
Pubmed Ho,
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.
1993,
Pubmed
,
Xenbase Inagaki,
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
1995,
Pubmed Johnson,
Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells.
1995,
Pubmed Krapivinsky,
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.
1995,
Pubmed
,
Xenbase Kubo,
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
1993,
Pubmed
,
Xenbase McNicholas,
Regulation of ROMK1 K+ channel activity involves phosphorylation processes.
1994,
Pubmed
,
Xenbase Methfessel,
Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels.
1986,
Pubmed
,
Xenbase Morishige,
Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brain.
1993,
Pubmed
,
Xenbase Périer,
Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.
1994,
Pubmed
,
Xenbase Schwiebert,
CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP.
1995,
Pubmed Sheppard,
Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.
1992,
Pubmed Sherry,
Differential acidic pH sensitivity of delta F508 CFTR Cl- channel activity in lipid bilayers.
1994,
Pubmed
,
Xenbase Standen,
The G. L. Brown Lecture. Potassium channels, metabolism and muscle.
1992,
Pubmed Stutts,
CFTR as a cAMP-dependent regulator of sodium channels.
1995,
Pubmed Suzuki,
Cloning of a pH-sensitive K+ channel possessing two transmembrane segments.
1994,
Pubmed Takano,
The ATP-sensitive K+ channel.
1993,
Pubmed Takumi,
A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells.
1995,
Pubmed
,
Xenbase Todd-Turla,
CFTR expression in cortical collecting duct cells.
1996,
Pubmed Wang,
Dual effect of adenosine triphosphate on the apical small conductance K+ channel of the rat cortical collecting duct.
1991,
Pubmed Wang,
A potassium channel in the apical membrane of rabbit thick ascending limb of Henle's loop.
1990,
Pubmed Wang,
Regulation of small-conductance K+ channel in apical membrane of rat cortical collecting tubule.
1990,
Pubmed Zhou,
Primary structure and functional properties of an epithelial K channel.
1994,
Pubmed
,
Xenbase
