Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Signaling molecules are essential for vertebrate embryonic development. Here, two Xenopus homologs of the Drosophila gene fringe, lunatic Fringe (lFng) and radical Fringe (rFng), were identified and the protein product of lFng further characterized. The messenger RNA of lFng is supplied as a maternal message. Its product is a precursor protein consisting of pre-, pro-, and mature regions. The mature lunatic Fringe protein is secreted extracellularly, and it induced mesodermal tissue formation in animal cap assays. These results indicate that secreted lunatic Fringe can induce mesoderm and reveal that the Fringe proteins are a family of vertebrate signaling molecules.
Amaya,
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
1991, Pubmed,
Xenbase
Amaya,
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
1991,
Pubmed
,
Xenbase Asashima,
Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor).
1990,
Pubmed
,
Xenbase Campbell,
Axis specification in the developing Drosophila appendage: the role of wingless, decapentaplegic, and the homeobox gene aristaless.
1993,
Pubmed Cornell,
Activin-mediated mesoderm induction requires FGF.
1994,
Pubmed
,
Xenbase Dale,
Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development.
1992,
Pubmed
,
Xenbase Dale,
Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vg1.
1993,
Pubmed
,
Xenbase Dawid,
Axis determination in Xenopus: gradients and signals.
1994,
Pubmed
,
Xenbase Green,
Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate.
1990,
Pubmed
,
Xenbase Green,
Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm.
1992,
Pubmed
,
Xenbase Harland,
In situ hybridization: an improved whole-mount method for Xenopus embryos.
1992,
Pubmed
,
Xenbase Hemmati-Brivanlou,
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos.
1992,
Pubmed
,
Xenbase Irvine,
fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.
1994,
Pubmed Jones,
Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation.
1995,
Pubmed
,
Xenbase Jones,
Inductive signals. Revolving vertebrates.
1995,
Pubmed
,
Xenbase Kessler,
Vertebrate embryonic induction: mesodermal and neural patterning.
1994,
Pubmed
,
Xenbase Kim,
Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing.
1995,
Pubmed Klein,
Hormonal regulation of embryogenesis: the formation of mesoderm in Xenopus laevis.
1994,
Pubmed
,
Xenbase Köster,
Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity.
1991,
Pubmed
,
Xenbase Matzuk,
Functional analysis of activins during mammalian development.
1995,
Pubmed
,
Xenbase Rao,
Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor.
1994,
Pubmed
,
Xenbase Rosa,
Mesoderm induction in amphibians: the role of TGF-beta 2-like factors.
1988,
Pubmed
,
Xenbase Schulte-Merker,
Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?
1994,
Pubmed
,
Xenbase Slack,
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors.
,
Pubmed
,
Xenbase Slack,
Inducing factors in Xenopus early embryos.
1994,
Pubmed
,
Xenbase Slack,
The role of fibroblast growth factor in early Xenopus development.
1989,
Pubmed
,
Xenbase Smith,
A mesoderm-inducing factor is produced by Xenopus cell line.
1987,
Pubmed
,
Xenbase Smith,
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.
1990,
Pubmed
,
Xenbase Sokol,
A mouse macrophage factor induces head structures and organizes a body axis in Xenopus.
1990,
Pubmed
,
Xenbase Tabata,
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs.
1994,
Pubmed Thomsen,
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.
1990,
Pubmed
,
Xenbase Thomsen,
Processed Vg1 protein is an axial mesoderm inducer in Xenopus.
1993,
Pubmed
,
Xenbase van den Eijnden-Van Raaij,
Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction.
1990,
Pubmed
,
Xenbase Vassalli,
Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.
1994,
Pubmed
,
Xenbase Weeks,
A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta.
1987,
Pubmed
,
Xenbase
