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The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family.
Galarneau L, Paré JF, Allard D, Hamel D, Levesque L, Tugwood JD, Green S, Bélanger L.
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The alpha1-fetoprotein (AFP) gene is located between the albumin and alpha-albumin genes and is activated by transcription factor FTF (fetoprotein transcription factor), presumed to transduce early developmental signals to the albumin gene cluster. We have identified FTF as an orphan nuclear receptor of the Drosophila FTZ-F1 family. FTF recognizes the DNA sequence 5'-TCAAGGTCA-3', the canonical recognition motif for FTZ-F1 receptors. cDNA sequence homologies indicate that rat FTF is the ortholog of mouse LRH-1 and Xenopus xFF1rA. Rodent FTF is encoded by a single-copy gene, related to the gene encoding steroidogenic factor 1 (SF-1). The 5.2-kb FTF transcript is translated from several in-frame initiator codons into FTF isoforms (54 to 64 kDa) which appear to bind DNA as monomers, with no need for a specific ligand, similar KdS (approximately equal 3 x 10(-10) M), and similar transcriptional effects. FTF activates the AFP promoter without the use of an amino-terminal activation domain; carboxy-terminus-truncated FTF exerts strong dominant negative effects. In the AFP promoter, FTF recruits an accessory trans-activator which imparts glucocorticoid reactivity upon the AFP gene. FTF binding sites are found in the promoters of other liver-expressed genes, some encoding liver transcription factors; FTF, liver alpha1-antitrypsin promoter factor LFB2, and HNF-3beta promoter factor UF2-H3beta are probably the same factor. FTF is also abundantly expressed in the pancreas and may exert differentiation functions in endodermal sublineages, similar to SF-1 in steroidogenic tissues. HepG2 hepatoma cells seem to express a mutated form of FTF.
Ang,
HNF-3 beta is essential for node and notochord formation in mouse development.
1994, Pubmed
Ang,
HNF-3 beta is essential for node and notochord formation in mouse development.
1994,
Pubmed Ayer,
Activation and repression of Drosophila alcohol dehydrogenase distal transcription by two steroid hormone receptor superfamily members binding to a common response element.
1993,
Pubmed Beato,
Steroid hormone receptors: many actors in search of a plot.
1995,
Pubmed Becker-André,
Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences.
1993,
Pubmed Belanger,
Hormonal regulation of alpha1 foetoprotein.
1975,
Pubmed Bélanger,
New albumin gene 3' adjacent to the alpha 1-fetoprotein locus.
1994,
Pubmed Bernier,
Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.
1993,
Pubmed Bois-Joyeux,
The c-jun proto-oncogene down-regulates the rat alpha-fetoprotein promoter in HepG2 hepatoma cells without binding to DNA.
1995,
Pubmed Brunel,
Interactions of DNA-binding proteins with the 5' region of the human transferrin gene.
1988,
Pubmed Cascio,
Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation.
1991,
Pubmed Chatterjee,
Repression of the human glycoprotein hormone alpha-subunit gene by glucocorticoids: evidence for receptor interactions with limiting transcriptional activators.
1991,
Pubmed Dignam,
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.
1983,
Pubmed Durand,
Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.
1994,
Pubmed
,
Xenbase Dziadek,
Modulation of alphafetoprotein synthesis in the early postimplantation mouse embryo.
1978,
Pubmed Ellinger-Ziegelbauer,
A naturally occurring short variant of the FTZ-F1-related nuclear orphan receptor xFF1rA and interactions between domains of xFF1rA.
1995,
Pubmed
,
Xenbase Ellinger-Ziegelbauer,
FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.
1994,
Pubmed
,
Xenbase Giguère,
Determinants of target gene specificity for ROR alpha 1: monomeric DNA binding by an orphan nuclear receptor.
1995,
Pubmed Gitlin,
Synthesis of serum albumin, prealbumin, alpha-foetoprotein, alpha-1-antitrypsin and transferrin by the human yolk sac.
1970,
Pubmed Guertin,
Rapid suppression of alpha 1-fetoprotein gene transcription by dexamethasone in developing rat liver.
1983,
Pubmed Guertin,
Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes.
1988,
Pubmed Hazel,
A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.
1988,
Pubmed Honda,
Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.
1993,
Pubmed Houart,
The alpha-foetoprotein proximal enhancer: localization, cell specificity and modulation by dexamethasone.
1990,
Pubmed Ikeda,
Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.
1993,
Pubmed Ingraham,
The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis.
1994,
Pubmed Issemann,
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.
1990,
Pubmed Jones,
Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro.
1985,
Pubmed Koike,
Molecular cloning and characterization of rat estrogen receptor cDNA.
1987,
Pubmed Kozak,
Adherence to the first-AUG rule when a second AUG codon follows closely upon the first.
1995,
Pubmed Laimins,
Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus.
1982,
Pubmed Lala,
Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I.
1992,
Pubmed Landschulz,
Isolation of a recombinant copy of the gene encoding C/EBP.
1988,
Pubmed Laudet,
Evolution of the nuclear receptor gene superfamily.
1992,
Pubmed Lavorgna,
Potential role for a FTZ-F1 steroid receptor superfamily member in the control of Drosophila metamorphosis.
1993,
Pubmed Lavorgna,
FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu.
1991,
Pubmed Le Douarin,
On the origin of pancreatic endocrine cells.
1988,
Pubmed Li,
Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1.
1994,
Pubmed López-Cabrera,
Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein.
1990,
Pubmed Mader,
Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element.
1989,
Pubmed Miesfeld,
Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA.
1986,
Pubmed Milbrandt,
Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.
1988,
Pubmed Monaci,
Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter.
1988,
Pubmed Morohashi,
A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s.
1992,
Pubmed Nakao,
c-Ha-ras down regulates the alpha-fetoprotein gene but not the albumin gene in human hepatoma cells.
1990,
Pubmed Nomura,
An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development.
1995,
Pubmed Ohno,
FTZ-F1 beta, a novel member of the Drosophila nuclear receptor family.
1993,
Pubmed Ohno,
The Drosophila nuclear receptors FTZ-F1 alpha and FTZ-F1 beta compete as monomers for binding to a site in the fushi tarazu gene.
1994,
Pubmed Pani,
The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor and positive autoactivation.
1992,
Pubmed Pinkert,
An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice.
1987,
Pubmed Renaud,
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.
1995,
Pubmed Segraves,
Something old, some things new: the steroid receptor superfamily in Drosophila.
1991,
Pubmed Strähle,
Synergistic action of the glucocorticoid receptor with transcription factors.
1988,
Pubmed Tsukiyama,
Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily.
1992,
Pubmed Turcotte,
Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones.
1990,
Pubmed Turcotte,
DNase I hypersensitivity and methylation of the 5'-flanking region of the alpha 1-fetoprotein gene during developmental and glucocorticoid-induced repression of its activity in rat liver.
1986,
Pubmed Ueda,
A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding protein.
1992,
Pubmed Umesono,
Determinants of target gene specificity for steroid/thyroid hormone receptors.
1989,
Pubmed Weinstein,
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.
1994,
Pubmed Wen,
A novel hepatocytic transcription factor that binds the alpha-fetoprotein promoter-linked coupling element.
1994,
Pubmed Wilson,
The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.
1993,
Pubmed Zhang,
Functional analysis of the trans-acting factor binding sites of the mouse alpha-fetoprotein proximal promoter by site-directed mutagenesis.
1991,
Pubmed
