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Retinoids are a large family of natural and synthetic compounds related to vitamin A that have pleiotropic effects on body physiology, reproduction, immunity, and embryonic development. The diverse activities of retinoids are primarily mediated by two families of nuclear retinoic acid receptors, the RARs and RXRs. Retinoic acids are thought to be the only natural ligands for these receptors and are widely assumed to be the active principle of vitamin A. However, during an unbiased, bioactivity-guided fractionation of Xenopus embryos, we were unable to detect significant levels of all-trans or 9-cis retinoic acids. Instead, we found that the major bioactive retinoid in the Xenopus egg and early embryo is 4-oxoretinaldehyde, which is capable of binding to and transactivating RARs. In addition to its inherent activity, 4-oxoretinaldehyde appears to be a metabolic precursor of two other RAR ligands, 4-oxoretinoic acid and 4-oxoretinol. The remarkable increase in activity of retinaldehyde and retinol as a consequence of 4-oxo derivatization suggests that this metabolic step could serve a critical regulatory function during embryogenesis.
Achkar,
4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.
1996, Pubmed,
Xenbase
Achkar,
4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.
1996,
Pubmed
,
Xenbase Blumberg,
Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg.
1992,
Pubmed
,
Xenbase Boehm,
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
1994,
Pubmed Brockes,
Retinoids, homeobox genes, and limb morphogenesis.
1989,
Pubmed Bryant,
Retinoic acid, local cell-cell interactions, and pattern formation in vertebrate limbs.
1992,
Pubmed Creech Kraft,
Temporal distribution, localization and metabolism of all-trans-retinol, didehydroretinol and all-trans-retinal during Xenopus development.
1994,
Pubmed
,
Xenbase Durston,
Retinoic acid causes an anteroposterior transformation in the developing central nervous system.
1989,
Pubmed
,
Xenbase Ellinger-Ziegelbauer,
A retinoic acid receptor expressed in the early development of Xenopus laevis.
1991,
Pubmed
,
Xenbase Heyman,
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.
1992,
Pubmed Hollenberg,
Multiple and cooperative trans-activation domains of the human glucocorticoid receptor.
1988,
Pubmed Kao,
The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos.
1988,
Pubmed
,
Xenbase Keidel,
Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping.
1994,
Pubmed Kraft,
The retinoid X receptor ligand, 9-cis-retinoic acid, is a potential regulator of early Xenopus development.
1994,
Pubmed
,
Xenbase Lammer,
Retinoic acid embryopathy.
1985,
Pubmed Leng,
Ligand-dependent conformational changes in thyroid hormone and retinoic acid receptors are potentially enhanced by heterodimerization with retinoic X receptor.
1993,
Pubmed Mangelsdorf,
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
1992,
Pubmed McClean,
Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials.
1982,
Pubmed Perlmann,
Determinants for selective RAR and TR recognition of direct repeat HREs.
1993,
Pubmed Pfeffer,
Regional specificity of RAR gamma isoforms in Xenopus development.
1994,
Pubmed
,
Xenbase Pijnappel,
The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification.
1993,
Pubmed
,
Xenbase Sharpe,
Two isoforms of retinoic acid receptor alpha expressed during Xenopus development respond to retinoic acid.
1992,
Pubmed
,
Xenbase Sive,
Progressive determination during formation of the anteroposterior axis in Xenopus laevis.
1989,
Pubmed
,
Xenbase
