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XB-ART-18687
Perspect Dev Neurobiol 1996 Jan 01;42-3:205-13.
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Calcium and chemotropic turning of nerve growth cones.

Zheng JQ, Poo MM, Connor JA.


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Cultured Xenopus spinal neurons exhibit chemotropic turning toward the source of neurotransmitters acetylcholine and glutamate. Here we review the experimental evidence that transmitter-induced turning of the growth cone is mediated by an influx of Ca2+, that a gradient of intracellular Ca2+ within the growth cone is responsible for the directional growth cone response, and that asymmetric filopodia formation precedes and is essential for the turning response.

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