Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
Yamashita H, ten Dijke P, Huylebroeck D, Sampath TK, Andries M, Smith JC, Heldin CH, Miyazono K.
???displayArticle.abstract???
Proteins in the TGF-beta superfamily transduce their effects through binding to type I and type II serine/threonine kinase receptors. Osteogenic protein-1 (OP-1, also known as bone morphogenetic protein-7 or BMP-7), a member of the TGF-beta superfamily which belongs to the BMP subfamily, was found to bind activin receptor type I (ActR-I), and BMP receptors type IA (BMPR-IA) and type IB (BMPR-IB) in the presence of activin receptors type II (ActR-II) and type IIB (ActR-IIB). The binding affinity of OP-1 to ActR-II was two- to threefold lower than that of activin A. A transcriptional activation signal was transduced after binding of OP-1 to the complex of ActR-I and ActR-II, or that of BMPR-IB and ActR-II. These results indicate that ActR-II can act as a functional type II receptor for OP-1, as well as for activins. Some of the known biological effects of activin were observed for OP-1, including growth inhibition and erythroid differentiation induction. Compared to activin, OP-1 was shown to be a poor inducer of mesoderm in Xenopus embryos. Moreover, follistatin, an inhibitor of activins, was found to inhibit the effects of OP-1, if added at a 10-fold excess. However, certain effects of activin, like induction of follicle stimulating hormone secretion in rat pituitary cells were not observed for OP-1. OP-1 has overlapping binding specificities with activins, and shares certain but not all of the functional effects of activins. Thus, OP-1 may have broader effects in vivo than hitherto recognized.
Andersson,
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
1989, Pubmed
Andersson,
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
1989,
Pubmed Attisano,
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors.
1992,
Pubmed Attisano,
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.
1993,
Pubmed Bassing,
A transforming growth factor beta type I receptor that signals to activate gene expression.
1994,
Pubmed Burt,
Evolution of the transforming growth factor-beta superfamily.
1994,
Pubmed Cárcamo,
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.
1994,
Pubmed Cooke,
The organization of mesodermal pattern in Xenopus laevis: experiments using a Xenopus mesoderm-inducing factor.
1987,
Pubmed
,
Xenbase Cunliffe,
Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.
1994,
Pubmed
,
Xenbase Dale,
Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development.
1992,
Pubmed
,
Xenbase Denef,
Cell-to-cell communication in peptide target cells of anterior pituitary.
1989,
Pubmed Ebner,
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.
1993,
Pubmed Ebner,
Determination of type I receptor specificity by the type II receptors for TGF-beta or activin.
1993,
Pubmed Estevez,
The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.
1993,
Pubmed Franzén,
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
1993,
Pubmed Frolik,
Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.
1984,
Pubmed Graff,
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo.
1994,
Pubmed
,
Xenbase He,
Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family.
1993,
Pubmed Hildén,
Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor.
1994,
Pubmed Howard,
Analysis of gastrulation: different types of gastrulation movement are induced by different mesoderm-inducing factors in Xenopus laevis.
1993,
Pubmed
,
Xenbase Huylebroeck,
Expression and processing of the activin-A/erythroid differentiation factor precursor: a member of the transforming growth factor-beta superfamily.
1990,
Pubmed Ichijo,
Characterization of in vivo phosphorylation of activin type II receptor.
1993,
Pubmed Inagaki,
Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA.
1993,
Pubmed Jones,
DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
1992,
Pubmed
,
Xenbase Jones,
Osteogenic protein-1 (OP-1) expression and processing in Chinese hamster ovary cells: isolation of a soluble complex containing the mature and pro-domains of OP-1.
1994,
Pubmed Kingsley,
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.
1994,
Pubmed Koenig,
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells.
1994,
Pubmed Laiho,
Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events.
1991,
Pubmed Laiho,
Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.
1990,
Pubmed Lin,
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
1992,
Pubmed Massagué,
The TGF-beta family and its composite receptors.
1994,
Pubmed Mathews,
Cloning of a second type of activin receptor and functional characterization in Xenopus embryos.
1992,
Pubmed
,
Xenbase Mathews,
Expression cloning of an activin receptor, a predicted transmembrane serine kinase.
1991,
Pubmed Mathews,
Activin receptors and cellular signaling by the receptor serine kinase family.
1994,
Pubmed Matsuzaki,
A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.
1993,
Pubmed Murata,
Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.
1988,
Pubmed Nakamura,
Activin-binding protein from rat ovary is follistatin.
1990,
Pubmed Ogawa,
Bovine bone activin enhances bone morphogenetic protein-induced ectopic bone formation.
1992,
Pubmed Okabe,
Long-term cultivation and differentiation of human erythroleukemia cells in a protein-free chemically defined medium.
1984,
Pubmed Okadome,
Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction.
1994,
Pubmed Ozkaynak,
OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.
1990,
Pubmed
,
Xenbase Paralkar,
Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen.
1992,
Pubmed Perides,
Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. Selective effects of the bone morphogenetic proteins.
1994,
Pubmed Reddi,
Regulation of cartilage and bone differentiation by bone morphogenetic proteins.
1992,
Pubmed Sampath,
Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.
1992,
Pubmed Schulte-Merker,
Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?
1994,
Pubmed
,
Xenbase Schwall,
Erythroid differentiation bioassays for activin.
1991,
Pubmed Slack,
Regional biosynthetic markers in the early amphibian embryo.
1984,
Pubmed Smith,
Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.
1991,
Pubmed
,
Xenbase Smith,
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.
1990,
Pubmed
,
Xenbase Smith,
Dorsalization and neural induction: properties of the organizer in Xenopus laevis.
1983,
Pubmed
,
Xenbase Suzuki,
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.
1994,
Pubmed
,
Xenbase ten Dijke,
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
1994,
Pubmed ten Dijke,
Characterization of type I receptors for transforming growth factor-beta and activin.
1994,
Pubmed ten Dijke,
Serine/threonine kinase receptors.
1994,
Pubmed ten Dijke,
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
1993,
Pubmed Thomsen,
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.
1990,
Pubmed
,
Xenbase Tsuchida,
Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor.
1993,
Pubmed Ueno,
Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.
1987,
Pubmed van den Eijnden-Van Raaij,
Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction.
1990,
Pubmed
,
Xenbase Vukicevic,
Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin.
1989,
Pubmed Wozney,
Bone morphogenetic proteins.
1989,
Pubmed Wrana,
Mechanism of activation of the TGF-beta receptor.
1994,
Pubmed Wrana,
TGF beta signals through a heteromeric protein kinase receptor complex.
1992,
Pubmed Xu,
Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.
1994,
Pubmed
