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XB-ART-1961
Bioorg Med Chem 2005 Jun 01;1311:3847-51. doi: 10.1016/j.bmc.2005.02.064.
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Mechanism of proliferation arrest of embryonic cells of Xenopus by diterpene compounds.

Okouchi T, Abe T, Araki S, Arai S, Iida T, Wang LY, Kitanaka S, Miyata S.


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Three diterpene compounds isolated from the anti-cancer herbal medicine kansui, namely, kansuinin B, 20-OD-ingenol Z, and 20-OD-ingenol E, specifically inhibited the proliferation of isolated embryonic cells from Xenopus embryos. We conducted a cytologic study to determine the mechanism underlying the arrest of the cellular proliferation by these compounds. While kansuinin B and 20-OD-ingenol Z treatment decreased the cell numbers in the S phase and the M phase substages of the cell cycle, 20-OD-ingenol E inhibited mitosis.

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