Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract??? Plakoglobin interacts with both classical and desmosomal cadherins. It is closely related to Drosophila aramadillo (arm) gene product; arm acts in the wingless (wg)-signaling pathway to establish segment polarity. In Xenopus, homologs of wg--i.e., wnts, can produce anterior axis duplications by inducing dorsal mesoderm. Studies in Drosophila suggest that wnt acts by increasing the level of cytoplasmic armadillo protein (arm). To test whether simply increasing the level of plakoglobin mimics the effects of exogenous wnts in Xenopus, we injected fertilized eggs with RNA encoding an epitope-tagged form of plakoglobin; this induced both early radial gastrulation and anterior axis duplication. Exogenous plakoglobin accumulates in the nuclei of embryonic cells. Plakoglobin binds to the tail domain of the desmosomal cadherin desmoglein 1. When RNA encoding the tail domain of desmoglein was coinjected with plakoglobin RNA, both the dorsalizing effect and nuclear accumulation of plakoglobin were suppressed. Mutational analysis indicates that the central arm repeat region of plakoglobin is sufficient to induce axis duplication and that this polypeptide accumulates in the nuclei of embryonic cells. These data show that increased plakoglobin levels can, by themselves, generate the intracellular signals involved in the specification of dorsal mesoderm.
Bejarano,
Mutants shed light on plant development.
1992, Pubmed
Bejarano,
Mutants shed light on plant development.
1992,
Pubmed Bradley,
Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.
1993,
Pubmed Burrus,
Wnt-1 as a short-range signaling molecule.
1994,
Pubmed
,
Xenbase Cary,
Vimentin's tail interacts with actin-containing structures in vivo.
1994,
Pubmed
,
Xenbase Cary,
Differential organization of desmin and vimentin in muscle is due to differences in their head domains.
1994,
Pubmed
,
Xenbase Cowin,
Plakoglobin: a protein common to different kinds of intercellular adhering junctions.
1986,
Pubmed DeMarais,
The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis.
1992,
Pubmed
,
Xenbase Evan,
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.
1985,
Pubmed
,
Xenbase Fortini,
An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye.
1993,
Pubmed Fouquet,
Identification of plakoglobin in oocytes and early embryos of Xenopus laevis: maternal expression of a gene encoding a junctional plaque protein.
1992,
Pubmed
,
Xenbase Funayama,
Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.
1995,
Pubmed
,
Xenbase Heasman,
Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.
1994,
Pubmed
,
Xenbase Hinck,
Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin.
1994,
Pubmed Hülsken,
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.
1994,
Pubmed Kao,
The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos.
1988,
Pubmed
,
Xenbase Kapprell,
Biochemical characterization of the soluble form of the junctional plaque protein, plakoglobin, from different cell types.
1987,
Pubmed Klymkowsky,
Evidence that the deep keratin filament systems of the Xenopus embryo act to ensure normal gastrulation.
1992,
Pubmed
,
Xenbase Knudsen,
Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.
1992,
Pubmed Kopan,
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD.
1994,
Pubmed Korman,
Demonstration of an adhering-junction molecule (plakoglobin) in the autoantigens of pemphigus foliaceus and pemphigus vulgaris.
1989,
Pubmed Kowalczyk,
Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability.
1994,
Pubmed Ku,
Xwnt-11: a maternally expressed Xenopus wnt gene.
1993,
Pubmed
,
Xenbase Legan,
The molecular biology of desmosomes and hemidesmosomes: "what's in a name"?
1992,
Pubmed Lieber,
Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.
1993,
Pubmed Mathur,
Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin.
1994,
Pubmed McCrea,
Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.
1993,
Pubmed
,
Xenbase McMahon,
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.
1989,
Pubmed
,
Xenbase Moon,
Dissecting Wnt signalling pathways and Wnt-sensitive developmental processes through transient misexpression analyses in embryos of Xenopus laevis.
1993,
Pubmed
,
Xenbase Noordermeer,
dishevelled and armadillo act in the wingless signalling pathway in Drosophila.
1994,
Pubmed Parkin,
Activity of Wnt-1 as a transmembrane protein.
1993,
Pubmed
,
Xenbase Peifer,
wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo.
1994,
Pubmed Peifer,
The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin.
1990,
Pubmed Peifer,
The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.
1992,
Pubmed
,
Xenbase Perrimon,
The genetic basis of patterned baldness in Drosophila.
1994,
Pubmed Rupp,
Xenopus embryos regulate the nuclear localization of XMyoD.
1994,
Pubmed
,
Xenbase Siegfried,
Components of wingless signalling in Drosophila.
1994,
Pubmed Sive,
The frog prince-ss: a molecular formula for dorsoventral patterning in Xenopus.
1993,
Pubmed
,
Xenbase Struhl,
Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo.
1993,
Pubmed Troyanovsky,
Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage.
1994,
Pubmed
