Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Biophys J
1994 Dec 01;676:2191-204. doi: 10.1016/S0006-3495(94)80705-2.
Show Gene links
Show Anatomy links
Properties of intracellular Ca2+ waves generated by a model based on Ca(2+)-induced Ca2+ release.
Dupont G, Goldbeter A.
???displayArticle.abstract???
Cytosolic Ca2+ waves occur in a number of cell types either spontaneously or after stimulation by hormones, neurotransmitters, or treatments promoting Ca2+ influx into the cells. These waves can be broadly classified into two types. Waves of type 1, observed in cardiac myocytes or Xenopus oocytes, correspond to the propagation of sharp bands of Ca2+ throughout the cell at a rate that is high enough to permit the simultaneous propagation of several fronts in a given cells. Waves of type 2, observed in hepatocytes, endothelial cells, or various kinds of eggs, correspond to the progressive elevation of cytosolic Ca2+ throughout the cell, followed by its quasi-homogeneous return down to basal levels. Here we analyze the propagation of these different types of intracellular Ca2+ waves in a model based on Ca(2+)-induced Ca2+ release (CICR). The model accounts for transient or sustained waves of type 1 or 2, depending on the size of the cell and on the values of the kinetic parameters that measure Ca2+ exchange between the cytosol, the extracellular medium, and intracellular stores. Two versions of the model based on CICR are considered. The first version involves two distinct Ca2+ pools sensitive to inositol 1,4,5-trisphosphate (IP3) and Ca2+, respectively, whereas the second version involves a single pool sensitive both to Ca2+ and IP3 behaving as co-agonists for Ca2+ release. Intracellular Ca2+ waves occur in the two versions of the model based on CICR, but fail to propagate in the one-pool model at subthreshold levels of IP3. For waves of type 1, we investigate the effect of the spatial distribution of Ca(2+)-sensitive Ca2+ stores within the cytosol, and show that the wave fails to propagate when the distance between the stores exceeds a critical value on the order of a few microns. We also determine how the period and velocity of the waves are affected by changes in parameters measuring stimulation, Ca2+ influx into the cell, or Ca2+ pumping into the stores. For waves of type 2, the numerical analysis indicates that the best qualitative agreement with experimental observations is obtained for phase waves. Finally, conditions are obtained for the occurrence of "echo" waves that are sometimes observed in the experiments.
Allbritton,
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.
1992, Pubmed,
Xenbase
Allbritton,
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.
1992,
Pubmed
,
Xenbase Amundson,
Calcium waves.
1993,
Pubmed
,
Xenbase Atri,
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte.
1993,
Pubmed
,
Xenbase Backx,
A model of propagating calcium-induced calcium release mediated by calcium diffusion.
1989,
Pubmed Berridge,
Calcium oscillations.
1990,
Pubmed Berridge,
Cytosolic calcium oscillators.
1988,
Pubmed Berridge,
Inositol trisphosphate and calcium signalling.
1993,
Pubmed Berridge,
Spatial and temporal signalling by calcium.
1994,
Pubmed Bezprozvanny,
Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum.
1991,
Pubmed Blatter,
Agonist-induced [Ca2+]i waves and Ca(2+)-induced Ca2+ release in mammalian vascular smooth muscle cells.
1992,
Pubmed Boitano,
Intercellular propagation of calcium waves mediated by inositol trisphosphate.
1992,
Pubmed Busa,
Activation of frog (Xenopus laevis) eggs by inositol trisphosphate. I. Characterization of Ca2+ release from intracellular stores.
1985,
Pubmed
,
Xenbase Camacho,
Increased frequency of calcium waves in Xenopus laevis oocytes that express a calcium-ATPase.
1993,
Pubmed
,
Xenbase Charles,
Intercellular signaling in glial cells: calcium waves and oscillations in response to mechanical stimulation and glutamate.
1991,
Pubmed Cheek,
Fertilisation and thimerosal stimulate similar calcium spiking patterns in mouse oocytes but by separate mechanisms.
1993,
Pubmed Cheer,
Cortical activity in vertebrate eggs. I: The activation waves.
1987,
Pubmed
,
Xenbase Cheng,
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle.
1993,
Pubmed Cuthbertson,
Modelling receptor-controlled intracellular calcium oscillators.
1991,
Pubmed DeLisle,
Inositol trisphosphate is required for the propagation of calcium waves in Xenopus oocytes.
1992,
Pubmed
,
Xenbase De Young,
A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.
1992,
Pubmed Donahue,
Free diffusion coefficient of ionic calcium in cytoplasm.
1987,
Pubmed Dupont,
Oscillations and waves of cytosolic calcium: insights from theoretical models.
1992,
Pubmed
,
Xenbase Dupont,
Signal-induced Ca2+ oscillations: properties of a model based on Ca(2+)-induced Ca2+ release.
1991,
Pubmed Dupont,
Latency correlates with period in a model for signal-induced Ca2+ oscillations based on Ca2(+)-induced Ca2+ release.
1990,
Pubmed Dupont,
One-pool model for Ca2+ oscillations involving Ca2+ and inositol 1,4,5-trisphosphate as co-agonists for Ca2+ release.
1993,
Pubmed Endo,
Properties of calcium release channels of the intracellular calcium store in muscle cells.
1990,
Pubmed Fewtrell,
Ca2+ oscillations in non-excitable cells.
1993,
Pubmed Finch,
Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release.
1991,
Pubmed Foskett,
Free cytoplasmic Ca2+ concentration oscillations in thapsigargin-treated parotid acinar cells are caffeine- and ryanodine-sensitive.
1991,
Pubmed Galione,
Ca(2+)-induced Ca2+ release and its modulation by cyclic ADP-ribose.
1992,
Pubmed Galione,
Redundant mechanisms of calcium-induced calcium release underlying calcium waves during fertilization of sea urchin eggs.
1993,
Pubmed
,
Xenbase Girard,
Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx.
1993,
Pubmed
,
Xenbase Girard,
Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes.
1992,
Pubmed
,
Xenbase Goldbeter,
Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation.
1990,
Pubmed Hoth,
Depletion of intracellular calcium stores activates a calcium current in mast cells.
1992,
Pubmed Jacob,
Imaging cytoplasmic free calcium in histamine stimulated endothelial cells and in fMet-Leu-Phe stimulated neutrophils.
1990,
Pubmed Jaffe,
Sources of calcium in egg activation: a review and hypothesis.
1983,
Pubmed Jaffe,
Classes and mechanisms of calcium waves.
1993,
Pubmed Jafri,
A membrane model for cytosolic calcium oscillations. A study using Xenopus oocytes.
1992,
Pubmed
,
Xenbase Kasai,
Subcellular distribution of Ca2+ release channels underlying Ca2+ waves and oscillations in exocrine pancreas.
1993,
Pubmed Kijima,
Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocytes.
1993,
Pubmed Kort,
Frequency, amplitude, and propagation velocity of spontaneous Ca++-dependent contractile waves in intact adult rat cardiac muscle and isolated myocytes.
1985,
Pubmed Kuba,
Simulation of intracellular Ca2+ oscillation in a sympathetic neurone.
1981,
Pubmed Kushmerick,
Ionic mobility in muscle cells.
1969,
Pubmed Law,
Thapsigargin, but not caffeine, blocks the ability of thyrotropin-releasing hormone to release Ca2+ from an intracellular store in GH4C1 pituitary cells.
1990,
Pubmed Lechleiter,
Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes.
1991,
Pubmed
,
Xenbase Lechleiter,
Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes.
1992,
Pubmed
,
Xenbase Lee,
Calcium mobilization by dual receptors during fertilization of sea urchin eggs.
1993,
Pubmed Lipp,
Modulation of Ca2+ release in cultured neonatal rat cardiac myocytes. Insight from subcellular release patterns revealed by confocal microscopy.
1994,
Pubmed Lipp,
Microscopic spiral waves reveal positive feedback in subcellular calcium signaling.
1993,
Pubmed Matsumoto,
Characteristics of the histamine-sensitive calcium store in vascular smooth muscle. Comparison with norepinephrine- or caffeine-sensitive stores.
1990,
Pubmed Meldolesi,
Intracellular Ca2+ storage organelles in non-muscle cells: heterogeneity and functional assignment.
1990,
Pubmed Meyer,
Highly cooperative opening of calcium channels by inositol 1,4,5-trisphosphate.
1988,
Pubmed Meyer,
Calcium spiking.
1991,
Pubmed Meyer,
Molecular model for receptor-stimulated calcium spiking.
1988,
Pubmed Meyer,
Cell signaling by second messenger waves.
1991,
Pubmed Mironov,
Theoretical analysis of Ca wave propagation along the surface of intracellular stores.
1990,
Pubmed Miyazaki,
Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs.
1992,
Pubmed Moses,
Sarcoplasmic reticulum and intermediate filament organization in cultured neonatal cardiac muscle cells. Studies with reduced osmium ferrocyanide.
1983,
Pubmed Nathanson,
Mechanism of Ca2+ wave propagation in pancreatic acinar cells.
1992,
Pubmed Parekh,
Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger.
1993,
Pubmed
,
Xenbase Parker,
Regenerative release of calcium from functionally discrete subcellular stores by inositol trisphosphate.
1991,
Pubmed
,
Xenbase Putney,
Capacitative calcium entry revisited.
1990,
Pubmed Randriamampita,
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx.
1993,
Pubmed Rooney,
Intracellular calcium waves generated by Ins(1,4,5)P3-dependent mechanisms.
1993,
Pubmed Sneyd,
Calcium wave propagation by calcium-induced calcium release: an unusual excitable system.
1993,
Pubmed Somogyi,
Hormone-induced calcium oscillations in liver cells can be explained by a simple one pool model.
1991,
Pubmed Speksnijder,
Periodic calcium waves cross ascidian eggs after fertilization.
1990,
Pubmed Stauderman,
The inositol 1,4,5-trisphosphate-forming agonist histamine activates a ryanodine-sensitive Ca2+ release mechanism in bovine adrenal chromaffin cells.
1991,
Pubmed Stern,
Theory of excitation-contraction coupling in cardiac muscle.
1992,
Pubmed Swillens,
Computer simulation of a cytosolic calcium oscillator.
1990,
Pubmed Takamatsu,
Calcium waves in mammalian heart: quantification of origin, magnitude, waveform, and velocity.
1990,
Pubmed Thomas,
Spatial and temporal organization of calcium signalling in hepatocytes.
1991,
Pubmed Tsien,
Calcium channels, stores, and oscillations.
1990,
Pubmed Wakui,
Receptor-activated cytoplasmic Ca2+ spiking mediated by inositol trisphosphate is due to Ca2(+)-induced Ca2+ release.
1990,
Pubmed Wakui,
Pulsatile intracellular calcium release does not depend on fluctuations in inositol trisphosphate concentration.
1989,
Pubmed Walton,
Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons.
1991,
Pubmed Woods,
Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes.
1987,
Pubmed Yagodin,
Nonlinear propagation of agonist-induced cytoplasmic calcium waves in single astrocytes.
1994,
Pubmed
