Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Telomerase activity in germline and embryonic cells of Xenopus.
Mantell LL, Greider CW.
???displayArticle.abstract??? Telomerase is a ribonucleoprotein which synthesizes telomere repeats onto chromosome ends. Telomerase activity is involved in telomere length maintenance. We used Xenopus laevis as a model system to study the expression of telomerase activity in germline cells and during early development. We identified a non-processive telomerase activity in manually dissected nuclei of Xenopus stage VI oocytes. Telomerase activity was detected throughout oogenesis and embryogenesis. Telomerase was active in both S and M phase cell cycle extracts, suggesting that telomerase activity is not regulated with chromosomal DNA replication.
Allshire,
Telomeric repeat from T. thermophila cross hybridizes with human telomeres.
1988, Pubmed
Allshire,
Telomeric repeat from T. thermophila cross hybridizes with human telomeres.
1988,
Pubmed Allsopp,
Telomere length predicts replicative capacity of human fibroblasts.
1992,
Pubmed Blackburn,
Structure and function of telomeres.
1991,
Pubmed Blow,
Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs.
1986,
Pubmed
,
Xenbase Cardenas,
A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins.
1993,
Pubmed
,
Xenbase Collins,
Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation.
1993,
Pubmed Counter,
Telomerase activity in human ovarian carcinoma.
1994,
Pubmed Counter,
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
1992,
Pubmed Danilchick,
Xenopus laevis: Practical uses in cell and molecular biology. Pictorial collage of embryonic stages.
1991,
Pubmed
,
Xenbase Dumont,
Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.
1972,
Pubmed
,
Xenbase Evans,
Biochemical fractionation of oocytes.
1991,
Pubmed
,
Xenbase Greider,
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
1985,
Pubmed Greider,
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity.
1987,
Pubmed Greider,
Telomerase is processive.
1991,
Pubmed Greider,
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
1989,
Pubmed Harley,
The telomere hypothesis of cellular aging.
1992,
Pubmed Harley,
Telomere loss: mitotic clock or genetic time bomb?
1991,
Pubmed Harley,
Telomeres shorten during ageing of human fibroblasts.
1990,
Pubmed Hastie,
Telomere reduction in human colorectal carcinoma and with ageing.
1990,
Pubmed Hutchison,
Periodic DNA synthesis in cell-free extracts of Xenopus eggs.
1987,
Pubmed
,
Xenbase Lohka,
Formation in vitro of sperm pronuclei and mitotic chromosomes induced by amphibian ooplasmic components.
1983,
Pubmed
,
Xenbase Marshak,
Characterization of synthetic peptide substrates for p34cdc2 protein kinase.
1991,
Pubmed Meyne,
Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
1989,
Pubmed Morin,
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.
1989,
Pubmed Murray,
Cell cycle extracts.
1991,
Pubmed Murray,
Cyclin synthesis drives the early embryonic cell cycle.
1989,
Pubmed
,
Xenbase Newport,
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.
1982,
Pubmed
,
Xenbase Newport,
Nuclear reconstitution in vitro: stages of assembly around protein-free DNA.
1987,
Pubmed
,
Xenbase Prowse,
Identification of a nonprocessive telomerase activity from mouse cells.
1993,
Pubmed Schmid,
Native yeast telomeres are sufficient to stabilize linear DNA in Xenopus laevis oocytes.
1991,
Pubmed
,
Xenbase Shippen-Lentz,
Functional evidence for an RNA template in telomerase.
1990,
Pubmed Smith,
Oogenesis and oocyte isolation.
1991,
Pubmed
,
Xenbase Smythe,
Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts.
1991,
Pubmed
,
Xenbase Taylor,
Quantitative changes in protein synthesis during oogenesis in Xenopus laevis.
1985,
Pubmed
,
Xenbase Vaziri,
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.
1993,
Pubmed Weber,
A linear vector carrying human telomeres is replicated in unfertilized eggs of Xenopus laevis.
1993,
Pubmed
,
Xenbase Wilson,
A trypsin-sensitive receptor on membrane vesicles is required for nuclear envelope formation in vitro.
1988,
Pubmed
,
Xenbase Yu,
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.
1990,
Pubmed Zahler,
Telomere terminal transferase activity in the hypotrichous ciliate Oxytricha nova and a model for replication of the ends of linear DNA molecules.
1988,
Pubmed
