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Some of the inducible forms of the heat shock protein 70 (Hsp70) gene family are encoded in the class III region of the major histocompatibility complex (MHC) of mammals. This study was undertaken to determine whether Hsp70 genes are linked to the MHC of Xenopus, an amphibian last sharing a common ancestor with mammals 300-350 million years ago. Segregation analyses involving seven haplotypes demonstrated the linkage of two or three inducible Hsp70 genes to the frog MHC. Another Hsp70 gene is not closely linked to the MHC. We conclude that the physical association of MHC class I and class II genes with Hsp70 genes is ancient.
Bevan,
High determinant density may explain the phenomenon of alloreactivity.
1984, Pubmed
Bevan,
High determinant density may explain the phenomenon of alloreactivity.
1984,
Pubmed Bienz,
Xenopus hsp 70 genes are constitutively expressed in injected oocytes.
1984,
Pubmed
,
Xenbase Brodsky,
The cell biology of antigen processing and presentation.
1991,
Pubmed Cameron,
Conservation of the central MHC genome: PFGE mapping and RFLP analysis of complement, HSP70, and TNF genes in the goat.
1990,
Pubmed Carroll,
Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.
1987,
Pubmed Craig,
SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein.
1989,
Pubmed DeNagel,
A case for chaperones in antigen processing.
1992,
Pubmed Deverson,
MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters.
,
Pubmed Dunham,
Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.
1987,
Pubmed Du Pasquier,
The expression of antibody diversity in natural and laboratory-made polyploid individuals of the clawed toad Xenopus.
1982,
Pubmed
,
Xenbase Dworniczak,
Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein.
1987,
Pubmed Feinberg,
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
1983,
Pubmed Flaherty,
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein.
1990,
Pubmed Flajnik,
The major histocompatibility complex of frogs.
1990,
Pubmed Flajnik,
Which came first, MHC class I or class II?
1991,
Pubmed Flynn,
Peptide binding and release by proteins implicated as catalysts of protein assembly.
1989,
Pubmed Foltz,
Sea urchin egg receptor for sperm: sequence similarity of binding domain and hsp70.
1993,
Pubmed Gaskins,
Localization of a mouse heat shock Hsp70 gene within the H-2 complex.
1990,
Pubmed Guillemot,
A molecular map of the chicken major histocompatibility complex: the class II beta genes are closely linked to the class I genes and the nucleolar organizer.
1988,
Pubmed Haas,
Immunoglobulin heavy chain binding protein.
,
Pubmed Harrison,
Chromosomal location of human genes encoding major heat-shock protein HSP70.
1987,
Pubmed Heikkila,
Acquisition of the heat-shock response and thermotolerance during early development of Xenopus laevis.
1985,
Pubmed
,
Xenbase Hunt,
Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.
1985,
Pubmed Ingolia,
Saccharomyces cerevisiae contains a complex multigene family related to the major heat shock-inducible gene of Drosophila.
1982,
Pubmed Jeffreys,
Linkage of adult alpha- and beta-globin genes in X. laevis and gene duplication by tetraploidization.
1980,
Pubmed
,
Xenbase Klein,
Evolution of the major histocompatibility complex.
1986,
Pubmed Koch,
A genetic polymorphism of the complement component factor B in chickens not linked to the major histocompatibility complex (MHC).
1986,
Pubmed Laird,
Simplified mammalian DNA isolation procedure.
1991,
Pubmed Lindquist,
The heat-shock response.
1986,
Pubmed Milner,
Structure and expression of the three MHC-linked HSP70 genes.
1990,
Pubmed Monaco,
Transport protein genes in the murine MHC: possible implications for antigen processing.
1990,
Pubmed Munro,
An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein.
1986,
Pubmed Nakamura,
Cosegregation of the polymorphic C4 with the MHC in the frog, Xenopus laevis.
1986,
Pubmed
,
Xenbase Nowak,
The optimal number of major histocompatibility complex molecules in an individual.
1992,
Pubmed Powis,
Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule.
1992,
Pubmed Rippmann,
A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA.
1991,
Pubmed Rothman,
Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells.
1989,
Pubmed Sargent,
Human major histocompatibility complex contains genes for the major heat shock protein HSP70.
1989,
Pubmed Sato,
Evolution of the MHC: isolation of class II beta-chain cDNA clones from the amphibian Xenopus laevis.
1993,
Pubmed
,
Xenbase Schubiger,
Linkage arrangement in the vitellogenin gene family of Xenopus laevis as revealed by gene segregation analysis.
1986,
Pubmed
,
Xenbase Spies,
A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway.
,
Pubmed Trowsdale,
Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters.
,
Pubmed Van Kaer,
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.
1992,
Pubmed Vidović,
Unresponsiveness to a foreign antigen can be caused by self-tolerance.
1988,
Pubmed von Boehmer,
Thymic selection: a matter of life and death.
1992,
Pubmed White,
Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man.
1985,
Pubmed Wurst,
Localization of heat shock protein 70 genes inside the rat major histocompatibility complex close to class III genes.
1989,
Pubmed
