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XB-ART-21786
J Cell Sci Suppl 1994 Jan 01;18:115-9. doi: 10.1242/jcs.1994.supplement_18.17.
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Regulation and function of the MAP kinase cascade in Xenopus oocytes.

Kosako H, Gotoh Y, Nishida E.


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In Xenopus oocytes, activation of MAP kinase occurs during meiotic maturation through a protein kinase cascade (the MAP kinase cascade), which is utilized commonly in various intracellular signaling pathways in eukaryotes. Studies with a neutralizing antibody against Xenopus MAP kinase kinase (MAPKK), a direct upstream activator for MAP kinase, have shown that the MAP kinase cascade plays a crucial role in both initiating oocyte maturation and inducing metaphase arrest.

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Species referenced: Xenopus
Genes referenced: mapk1