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XB-ART-22454
Neuroendocrinology 1993 Jul 01;581:80-5. doi: 10.1159/000126516.
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Dual action of GABAA receptors on the secretory process of melanotrophs of Xenopus laevis.

Jenks BG, de Koning HP, Valentijn K, Roubos EW.


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The effects of GABAa receptor activation on the secretion of alpha-melanocyte-stimulating hormone (alpha-MSH) from the superfused pars intermedia of the amphibian Xenopus laevis were examined. The GABAa receptor agonist isoguvacine inhibited secretion of alpha-MSH from the pars intermedia, an action completely antagonized by the chloride channel blocker picrotoxin. Isoguvacine stimulated secretion from picrotoxin-treated tissue. Both effects were blocked by the GABAA receptor antagonist bicuculline, indicating that it is a specific action via the GABAA receptor. We conclude that, besides the inhibitory chloride channel, there is a stimulatory signaling property associated with the GABAA receptor. Isoguvacine stimulated the production of c-AMP, an action that was not blocked by picrotoxin. This suggests that the stimulatory mechanism of the GABAA receptor involves, directly or indirectly, the generation of c-AMP.

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Species referenced: Xenopus laevis
Genes referenced: gabarap