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Mol Cell Biol
1993 May 01;135:2942-51. doi: 10.1128/mcb.13.5.2942-2951.1993.
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Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region.
Jiang YP, Wang H, D'Eustachio P, Musacchio JM, Schlessinger J, Sap J.
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We describe a new member of the receptor protein tyrosine phosphatase family, R-PTP-kappa, cDNA cloning predicts that R-PTP-kappa is synthesized from a precursor protein of 1,457 amino acids. Its intracellular domain displays the classical tandemly repeated protein tyrosine phosphatase homology, separated from the transmembrane segment by an uncharacteristically large juxta-membrane region. The extracellular domain of the R-PTP-kappa precursor protein contains an immunoglobulin-like domain and four fibronectin type III-like repeats, preceded by a signal peptide and a region of about 150 amino acids with similarity to the Xenopus A5 antigen, a putative neuronal recognition molecule (S. Takagi, T. Hsrata, K. Agata, M. Mochii, G. Eguchi, and H. Fujisawa, Neuron 7:295-307, 1991). Antibodies directed against the intra- and extracellular domains reveal that the R-PTP-kappa precursor protein undergoes proteolytic processing, following which both cleavage products remain associated. By site-directed mutagenesis, the likely cleavage site was shown to be a consensus sequence for cleavage by the processing endopeptidase furin, located in the fourth fibronectin type III-like repeat. In situ hybridization analysis indicates that expression of R-PTP-kappa in the central nervous system is developmentally regulated, with highest expression seen in actively developing areas and, in the adult, in areas capable of developmental plasticity such as the hippocampal formation and cerebral cortex. The mouse R-PTP-kappa gene maps to chromosome 10, at approximately 21 centimorgans from the centromere.
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Atashi,
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Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.
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Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.
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Pubmed Nishi,
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Pubmed O'Bryan,
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Pubmed Ostergaard,
Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.
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Pubmed Rescigno,
A putative receptor tyrosine kinase with unique structural topology.
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Pubmed Rohrschneider,
Adhesion plaques of Rous sarcoma virus-transformed cells contain the src gene product.
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Pubmed Rubin,
Signal transduction and the fate of the R7 photoreceptor in Drosophila.
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Pubmed Samelson,
Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.
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Pubmed Sap,
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Pubmed Silver,
Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains.
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Pubmed Streuli,
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Pubmed Streuli,
Expression of the receptor-linked protein tyrosine phosphatase LAR: proteolytic cleavage and shedding of the CAM-like extracellular region.
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,
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Pubmed
