Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Mol Cell Biol
1993 May 01;135:2765-75. doi: 10.1128/mcb.13.5.2765-2775.1993.
Show Gene links
Show Anatomy links
Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution.
Schreiber-Agus N, Horner J, Torres R, Chiu FC, DePinho RA.
???displayArticle.abstract???
To gain insight into the role of Myc family oncoproteins and their associated protein Max in vertebrate growth and development, we sought to identify homologs in the zebra fish (Brachydanio rerio). A combination of a polymerase chain reaction-based cloning strategy and low-stringency hybridization screening allowed for the isolation of zebra fish c-, N-, and L-myc and max genes; subsequent structural characterization showed a high degree of conservation in regions that encode motifs of known functional significance. On the functional level, zebra fish Max, like its mammalian counterpart, served to suppress the transformation activity of mouse c-Myc in rat embryo fibroblasts. In addition, the zebra fish c-myc gene proved capable of cooperating with an activated H-ras to effect the malignant transformation of mammalian cells, albeit with diminished potency compared with mouse c-myc. With respect to their roles in normal developing tissues, the differential temporal and spatial patterns of steady-state mRNA expression observed for each zebra fish myc family member suggest unique functions for L-myc in early embryogenesis, for N-myc in establishment and growth of early organ systems, and for c-myc in increasingly differentiated tissues. Furthermore, significant alterations in the steady-state expression of zebra fish myc family genes concomitant with relatively constant max expression support the emerging model of regulation of Myc function in cellular growth and differentiation.
Andersson,
A defined subgenomic fragment of in vitro synthesized Moloney sarcoma virus DNA can induce cell transformation upon transfection.
1979, Pubmed
Andersson,
A defined subgenomic fragment of in vitro synthesized Moloney sarcoma virus DNA can induce cell transformation upon transfection.
1979,
Pubmed Auffray,
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.
1980,
Pubmed Ayer,
Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.
1993,
Pubmed Barrett,
Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells.
1992,
Pubmed Berberich,
Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers.
1992,
Pubmed Blackwood,
Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc.
1991,
Pubmed Blackwood,
Myc and Max associate in vivo.
1992,
Pubmed Bonnieu,
Sequence determinants of c-myc mRNA turn-over: influence of 3' and 5' non-coding regions.
1988,
Pubmed Brewer,
Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.
1988,
Pubmed Charron,
Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.
1992,
Pubmed Cole,
Myc meets its Max.
1991,
Pubmed DePinho,
The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.
1987,
Pubmed DePinho,
myc family oncogenes in the development of normal and neoplastic cells.
1991,
Pubmed DePinho,
Structure and expression of the murine N-myc gene.
1986,
Pubmed Devereux,
A comprehensive set of sequence analysis programs for the VAX.
1984,
Pubmed Downs,
Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo.
1989,
Pubmed Fasano,
Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells.
1983,
Pubmed Gazin,
Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon.
1984,
Pubmed Jones,
Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences.
1987,
Pubmed Kato,
An amino-terminal c-myc domain required for neoplastic transformation activates transcription.
1990,
Pubmed Kato,
Max: functional domains and interaction with c-Myc.
1992,
Pubmed Kenyon,
The nematode Caenorhabditis elegans.
1988,
Pubmed Kimmel,
Genetics and early development of zebrafish.
1989,
Pubmed Kretzner,
Myc and Max proteins possess distinct transcriptional activities.
1992,
Pubmed Land,
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.
,
Pubmed Legouy,
Structure and expression of the murine L-myc gene.
1987,
Pubmed Mäkelä,
Alternative forms of Max as enhancers or suppressors of Myc-ras cotransformation.
1992,
Pubmed Maxam,
Sequencing end-labeled DNA with base-specific chemical cleavages.
1980,
Pubmed McBurney,
Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line.
1982,
Pubmed Mukherjee,
Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants.
1992,
Pubmed Prendergast,
A new bind for Myc.
1992,
Pubmed Prendergast,
Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation.
1991,
Pubmed Principaud,
Xenopus laevis c-myc I and II genes: molecular structure and developmental expression.
1991,
Pubmed
,
Xenbase Rossant,
Of fin and fur: mutational analysis of vertebrate embryonic development.
1992,
Pubmed Rubin,
Drosophila melanogaster as an experimental organism.
1988,
Pubmed Schreiber-Agus,
Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs.
1993,
Pubmed
,
Xenbase Stanton,
Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.
1992,
Pubmed Stanton,
Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas.
,
Pubmed Stanton,
Nucleotide sequence comparison of normal and translocated murine c-myc genes.
,
Pubmed Stone,
Definition of regions in human c-myc that are involved in transformation and nuclear localization.
1987,
Pubmed Streisinger,
Production of clones of homozygous diploid zebra fish (Brachydanio rerio).
1981,
Pubmed Torres,
Myc and Max: a putative transcriptional complex in search of a cellular target.
1992,
Pubmed Tso,
Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene.
1985,
Pubmed Van Beneden,
Cellular myc (c-myc) in fish (rainbow trout): its relationship to other vertebrate myc genes and to the transforming genes of the MC29 family of viruses.
1986,
Pubmed Vize,
Expression of the N-myc proto-oncogene during the early development of Xenopus laevis.
1990,
Pubmed
,
Xenbase Vriz,
Differential expression of two Xenopus c-myc proto-oncogenes during development.
1989,
Pubmed
,
Xenbase Wagner,
Expression, regulation, and chromosomal localization of the Max gene.
1992,
Pubmed Wenzel,
The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells.
1991,
Pubmed Zervos,
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites.
1993,
Pubmed Zimmerman,
Differential expression of myc family genes during murine development.
,
Pubmed
