Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-24730
Neuron 1991 Jul 01;71:45-57.
Show Gene links Show Anatomy links

Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS.

Snutch TP, Tomlinson WJ, Leonard JP, Gilbert MM.


???displayArticle.abstract???
A number of pharmacologically and electrophysiologically distinct voltage-dependent Ca2+ channels have been identified in mammalian neurons. Two rat brain Ca2+ channel alpha 1 subunits (rbC-I and rbC-II) have been isolated by molecular cloning and shown to be highly related (95%) to the cardiac dihydropyridine-sensitive Ca2+ channel. The rbC-II protein is distinct from rbC-I in that it contains a 3 amino acid insert in the putative cytoplasmic loop between domains II and III and a 28 amino acid substitution corresponding to the third transmembrane segment (S3) of the fourth domain. We show that rbC-I and rbC-II transcripts are generated by alternative splicing and that they are differentially expressed in the rat CNS.

???displayArticle.pubmedLink??? 1648941
???displayArticle.link??? Neuron
???displayArticle.grants??? [+]