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Mol Cell Biol
1991 Jan 01;111:412-24. doi: 10.1128/mcb.11.1.412-424.1991.
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The Xenopus B1 factor is closely related to the mammalian activator USF and is implicated in the developmental regulation of TFIIIA gene expression.
Kaulen H, Pognonec P, Gregor PD, Roeder RG.
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The Xenopus laevis TFIIIA promoter contains a motif that has been implicated in promoter activation in late-stage oocytes and contains the sequence (-269) CACGTG (-264). A cDNA encoding a protein (B1) that binds to this element has been cloned from X. laevis and Xenopus borealis ovarian cDNA libraries. We show that this protein is a member of the helix-loop-helix family of regulatory proteins and contains 80% sequence identity with the human adenovirus major late transcription factor (MLTF or USF). A survey of B1 protein expression during oogenesis and embryogenesis revealed both oocyte-specific and somatic cell-specific B1 protein-DNA complexes. Immunological data, RNA blot analysis, and proteolytic clipping band shift assays indicated that these complexes most likely represent altered forms of a single B1 polypeptide. Implications for TFIIIA gene regulation during development are discussed.
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Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.
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,
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Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult beta-globin gene: nature of the binding domain.
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,
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,
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,
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,
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Developmental regulation of a gastrula-specific gene injected into fertilized Xenopus eggs.
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,
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
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The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.
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Upstream sequences required for transcription of the TFIIIA gene in Xenopus oocytes.
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,
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Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.
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A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.
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,
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,
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,
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,
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Pubmed
,
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The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc.
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Developmental regulation of Xenopus 5S RNA genes.
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,
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