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XB-ART-25646
Genes Dev 1990 Sep 01;49:1602-10. doi: 10.1101/gad.4.9.1602.
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The characterization of the TFIIIA synthesized in somatic cells of Xenopus laevis.

Kim SH, Darby MK, Joho KE, Brown DD.


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In somatic cells of Xenopus, transcription of the TFIIIA gene initiates greater than 200 bp upstream from the start site used in oocytes. The resultant mRNA encodes a protein, S-TFIIIA, that is 22 amino acids longer at its amino terminus than the abundant form of TFIIIA in oocytes (O-TFIIIA). S-TFIIIA binds the 5S RNA gene and 5S RNA, and both O- and S-TFIIIA promote the formation of stable transcription complexes on oocyte-type 5S RNA genes in an oocyte nuclear extract. We have not found any functional difference between the two forms of TFIIIA. Different transcription start sites suggest differential promoter usage--one in oocytes that permits high levels of gene activity and another that is used in somatic cells for low-level TFIIIA mRNA synthesis.

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Species referenced: Xenopus laevis
Genes referenced: gtf3a