Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
EMBO J
1990 Jun 01;96:1839-52. doi: 10.1002/j.1460-2075.1990.tb08309.x.
Show Gene links
Show Anatomy links
A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner.
Bastian H, Gruss P.
???displayArticle.abstract???
Using the Drosophila even-skipped (eve) homeobox as a probe, we have isolated two murine genes, Evx 1 and Evx 2, from a genomic library. Evx 1, Evx 2, eve and the Xenopus Xhox-3 constitute a family of related genes based on similar homeodomain sequences. In addition, Evx 1 and Evx 2 share extended amino acid conservation outside of the homeobox. The Evx 1 protein consists of 416 amino acids as deduced from the longest open reading frame of Evx 1 cDNAs. Evx 1 is located 3.7 cM from the Hox 5 locus on mouse chromosome 2. It is expressed in undifferentiated F9 stem cells but not in cells differentiated with retinoic acid and cAMP. During embryogenesis, Evx 1 shows a biphasic expression pattern. From days 7 to 9 p.c. Evx 1 expression emerges at the posterior end of the embryo within the primitive ectoderm, and later in the mesoderm and neuroectoderm. From days 10 to 12.5 p.c. Evx 1 transcripts are restricted to specific cells within the neural tube and hindbrain along their entire lengths and coincides temporally, as well as spatially, with maturation of early forming interneurons, possibly commissural interneurons. The early and late transcription pattern is compatible with a role of Evx 1 in specifying posterior positional information along the embryonic axis similar to the Xenopus Xhox-3 and in specifying neuronal cell fates within the differentiating neural tube in analogy to eve in the embryonic central nervous system of Drosophila, respectively.
Akam,
The molecular basis for metameric pattern in the Drosophila embryo.
1987, Pubmed
Akam,
The molecular basis for metameric pattern in the Drosophila embryo.
1987,
Pubmed Balling,
Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice.
1989,
Pubmed Balling,
undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1.
1988,
Pubmed Berstine,
Alkaline phosphatase activity in mouse teratoma.
1973,
Pubmed Biggin,
A purified Drosophila homeodomain protein represses transcription in vitro.
1989,
Pubmed Bopp,
Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro.
1989,
Pubmed Bopp,
Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila.
1986,
Pubmed Burri,
Conservation of the paired domain in metazoans and its structure in three isolated human genes.
1989,
Pubmed Cho,
Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity.
1988,
Pubmed
,
Xenbase Davidson,
A gene with sequence similarity to Drosophila engrailed is expressed during the development of the neural tube and vertebrae in the mouse.
1988,
Pubmed Davis,
Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.
1988,
Pubmed Dearolf,
The caudal gene product is a direct activator of fushi tarazu transcription during Drosophila embryogenesis.
1989,
Pubmed De Robertis,
Determination of axial polarity in the vertebrate embryo: homeodomain proteins and homeogenetic induction.
1989,
Pubmed
,
Xenbase Deutsch,
Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development.
1988,
Pubmed Doe,
Segmentation and homeotic gene function in the developing nervous system of Drosophila.
1988,
Pubmed Doe,
Control of neuronal fate by the Drosophila segmentation gene even-skipped.
1988,
Pubmed Dressler,
Do multigene families regulate vertebrate development?
1988,
Pubmed Duboule,
The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.
1989,
Pubmed Duprey,
A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.
1988,
Pubmed Elsdale,
Somitogenesis in amphibia. IV. The dynamics of tail development.
1983,
Pubmed Fahrner,
Transcription of H-2 and Qa genes in embryonic and adult mice.
1987,
Pubmed Featherstone,
Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2.
1988,
Pubmed
,
Xenbase Feinberg,
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
1983,
Pubmed Frasch,
Molecular analysis of even-skipped mutants in Drosophila development.
1988,
Pubmed Frasch,
Characterization and localization of the even-skipped protein of Drosophila.
1987,
Pubmed FUJITA,
ANALYSIS OF NEURON DIFFERENTIATION IN THE CENTRAL NERVOUS SYSTEM BY TRITIATED THYMIDINE AUTORADIOGRAPHY.
1964,
Pubmed Goto,
Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues.
1989,
Pubmed Graham,
The murine and Drosophila homeobox gene complexes have common features of organization and expression.
1989,
Pubmed Harding,
Autoregulatory and gap gene response elements of the even-skipped promoter of Drosophila.
1989,
Pubmed Harvey,
Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos.
1988,
Pubmed
,
Xenbase Hoey,
DNA-binding activities of the Drosophila melanogaster even-skipped protein are mediated by its homeo domain and influenced by protein context.
1988,
Pubmed Hoey,
Divergent homeo box proteins recognize similar DNA sequences in Drosophila.
1988,
Pubmed Holland,
Expression of homeo box genes during mouse development: a review.
1988,
Pubmed Holley,
Guidance of neuritic growth in the transverse plane of embryonic mouse spinal cord.
1982,
Pubmed Ingham,
The molecular genetics of embryonic pattern formation in Drosophila.
1988,
Pubmed Ingham,
Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped.
1988,
Pubmed Joyner,
En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.
1987,
Pubmed Lumsden,
Segmental patterns of neuronal development in the chick hindbrain.
1989,
Pubmed Macdonald,
Isolation, structure, and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeo box.
1986,
Pubmed Martin,
Teratocarcinomas and mammalian embryogenesis.
1980,
Pubmed McGinnis,
A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans.
1984,
Pubmed Moffie,
Pain and neuroma formation in Wallenberg's lateral medullary syndrome.
1986,
Pubmed Murphy,
Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain.
1989,
Pubmed Nornes,
Neurogenesis in spinal cord of mouse: an autoradiographic analysis.
1978,
Pubmed Nornes,
Temporal pattern of neurogenesis in spinal cord of rat. I. An autoradiographic study--time and sites of origin and migration and settling patterns of neuroblasts.
1974,
Pubmed Nüsslein-Volhard,
Genes affecting the segmental subdivision of the Drosophila embryo.
1985,
Pubmed Otting,
Secondary structure determination for the Antennapedia homeodomain by nuclear magnetic resonance and evidence for a helix-turn-helix motif.
1988,
Pubmed Patel,
Expression of engrailed proteins in arthropods, annelids, and chordates.
1989,
Pubmed
,
Xenbase Patel,
The role of segment polarity genes during Drosophila neurogenesis.
1989,
Pubmed Poole,
The engrailed locus of Drosophila: structural analysis of an embryonic transcript.
1985,
Pubmed Robert,
Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis.
1989,
Pubmed Ruiz i Altaba,
Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos.
1989,
Pubmed
,
Xenbase Ruiz i Altaba,
Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during embryonic development.
1989,
Pubmed
,
Xenbase Sakai,
Neurulation in the mouse. I. The ontogenesis of neural segments and the determination of topographical regions in a central nervous system.
1987,
Pubmed Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed Schughart,
Duplication of large genomic regions during the evolution of vertebrate homeobox genes.
1989,
Pubmed Scott,
Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.
1984,
Pubmed Scott,
The structure and function of the homeodomain.
1989,
Pubmed Shapiro,
RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.
1987,
Pubmed SIDMAN,
Cell proliferation and migration in the primitive ependymal zone: an autoradiographic study of histogenesis in the nervous system.
1959,
Pubmed Siracusa,
A molecular genetic linkage map of mouse chromosome 2.
1990,
Pubmed Slack,
The role of fibroblast growth factor in early Xenopus development.
1989,
Pubmed
,
Xenbase Smart,
Proliferative characteristics of the ependymal layer during the early development of the spinal cord in the mouse.
1972,
Pubmed Smith,
Inducing factors and the control of mesodermal pattern in Xenopus laevis.
1989,
Pubmed
,
Xenbase Stern,
Spatial patterns of homeobox gene expression in the developing mammalian CNS.
1988,
Pubmed Strickland,
Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP.
1980,
Pubmed Tam,
The histogenetic capacity of tissues in the caudal end of the embryonic axis of the mouse.
1984,
Pubmed Tuckett,
The ontogenesis of cranial neuromeres in the rat embryo. I. A scanning electron microscope and kinetic study.
1985,
Pubmed Wentworth,
The development of the cervical spinal cord of the mouse embryo. II. A Golgi analysis of sensory, commissural, and association cell differentiation.
1984,
Pubmed Wharton,
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats.
1985,
Pubmed Wilkinson,
Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo.
1987,
Pubmed Wilkinson,
Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse.
1989,
Pubmed Wilkinson,
Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain.
1989,
Pubmed Wolgemuth,
Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development.
1989,
Pubmed Wright,
Vertebrate homeodomain proteins: families of region-specific transcription factors.
1989,
Pubmed
,
Xenbase
