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Mol Cell Biol
1990 May 01;105:2413-7. doi: 10.1128/mcb.10.5.2413-2417.1990.
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Identification of mitogen-responsive ribosomal protein S6 kinase pp90rsk, a homolog of Xenopus S6 kinase II, in chicken embryo fibroblasts.
Sweet LJ, Alcorta DA, Jones SW, Erikson E, Erikson RL.
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Antiserum raised against recombinant Xenopus ribosomal protein S6 kinase (rsk) was used to identify a 90,000-Mr ribosomal S6 kinase, pp90rsk, in chicken embryo fibroblasts. Adding serum to cells stimulated the phosphorylation of pp90rsk on serine and threonine residues and increased the activity of S6 kinase measured in immune complex assays. Xenopus S6 kinase II and chicken embryofibroblast pp90rsk had nearly identical phosphopeptide maps.
Alcorta,
Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.
1989, Pubmed,
Xenbase
Alcorta,
Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.
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S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment.
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Identification of a ribosomal protein S6 kinase regulated by transformation and growth-promoting stimuli.
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Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6.
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Structural analysis of the avian sarcoma virus transforming protein: sites of phosphorylation.
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Phosphorylation of ribosomal protein S6 in avian sarcoma virus-transformed chicken embryo fibroblasts.
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In vivo phosphorylation and activation of ribosomal protein S6 kinases during Xenopus oocyte maturation.
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Purification and characterization of a protein kinase from Xenopus eggs highly specific for ribosomal protein S6.
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A protein kinase from Xenopus eggs specific for ribosomal protein S6.
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Antibodies to Xenopus egg S6 kinase II recognize S6 kinase from progesterone- and insulin-stimulated Xenopus oocytes and from proliferating chicken embryo fibroblasts.
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Identification and characterization of a mitogen-activated S6 kinase.
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A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
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EGF, PGF2 alpha and insulin induce the phosphorylation of identical S6 peptides in swiss mouse 3T3 cells: effect of cAMP on early sites of phosphorylation.
1984,
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An S6 kinase activated during liver regeneration is related to the insulin-stimulated S6 kinase in H4 hepatoma cells.
1988,
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Insulin-treated 3T3-L1 adipocytes and cell-free extracts derived from them incorporate 32P into ribosomal protein S6.
1980,
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Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.
1988,
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EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity.
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Purification of a bovine liver S6 kinase.
1987,
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The effect of serum, EGF, PGF2 alpha and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis.
1982,
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Insulin- and phorbol ester-stimulated phosphorylation of ribosomal protein S6.
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The structure and function of eukaryotic ribosomes.
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