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XB-ART-26136
Science 1990 Jan 19;2474940:327-9.
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Microinjection of a conserved peptide sequence of p34cdc2 induces a Ca2+ transient in oocytes.

Picard A, Cavadore JC, Lory P, Bernengo JC, Ojeda C, Dorée M.


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The product of the yeast cell cycle control gene cdc2, and its homologs in higher eukaryotes (p34cdc2), all contain a perfectly conserved sequence of 16 amino acids that has not been found in any other protein sequence. Microinjection of this peptide triggers a specific increase in the concentration of intracellular free Ca2+ that originates from intracellular stores in both starfish and Xenopus oocytes. Thus, p34cdc2 might interact through its conserved peptide domain with some component of the Ca2(+)-regulatory system.

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Species referenced: Xenopus
Genes referenced: cdk1 pold1