Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
EMBO J
1989 Nov 01;811:3235-44. doi: 10.1002/j.1460-2075.1989.tb08483.x.
Show Gene links
Show Anatomy links
Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
Stühmer W, Ruppersberg JP, Schröter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, Pongs O.
???displayArticle.abstract???
Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.
Baumann,
Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems.
1988, Pubmed
Baumann,
Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems.
1988,
Pubmed Benton,
Screening lambdagt recombinant clones by hybridization to single plaques in situ.
1977,
Pubmed Black,
Two acceptor sub-types for dendrotoxin in chick synaptic membranes distinguishable by beta-bungarotoxin.
1986,
Pubmed Butler,
A family of putative potassium channel genes in Drosophila.
1989,
Pubmed Catterall,
Structure and function of voltage-sensitive ion channels.
1988,
Pubmed Christie,
Expression of a cloned rat brain potassium channel in Xenopus oocytes.
1989,
Pubmed
,
Xenbase Dreyer,
The actions of presynaptic snake toxins on membrane currents of mouse motor nerve terminals.
1987,
Pubmed Halliwell,
Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors.
1986,
Pubmed Harris,
Changes in densities and kinetics of delayed rectifier potassium channels during neuronal differentiation.
1988,
Pubmed
,
Xenbase Hoshi,
Gating kinetics of four classes of voltage-dependent K+ channels in pheochromocytoma cells.
1988,
Pubmed Hoshi,
Voltage-dependent K+ currents and underlying single K+ channels in pheochromocytoma cells.
1988,
Pubmed Imoto,
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance.
1988,
Pubmed
,
Xenbase Iverson,
A-type potassium channels expressed from Shaker locus cDNA.
1988,
Pubmed
,
Xenbase Jan,
Voltage-sensitive ion channels.
1989,
Pubmed Kamb,
Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity.
1988,
Pubmed Kasai,
Single transient K channels in mammalian sensory neurons.
1986,
Pubmed Krebs,
Phosphorylation-dephosphorylation of enzymes.
1979,
Pubmed Kyte,
A simple method for displaying the hydropathic character of a protein.
1982,
Pubmed Latorre,
K+ channels gated by voltage and ions.
1984,
Pubmed Lewis,
The plasticity of ion channels: parallels between the nervous and immune systems.
1988,
Pubmed Lin,
An improved DNA sequencing strategy.
1985,
Pubmed MacKinnon,
Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features.
1988,
Pubmed
,
Xenbase Marty,
Potassium channels in cultured bovine adrenal chromaffin cells.
1985,
Pubmed McGinnis,
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes.
,
Pubmed McKinnon,
Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family.
1989,
Pubmed
,
Xenbase Methfessel,
Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels.
1986,
Pubmed
,
Xenbase Moczydlowski,
An emerging pharmacology of peptide toxins targeted against potassium channels.
1988,
Pubmed Noda,
Existence of distinct sodium channel messenger RNAs in rat brain.
,
Pubmed Noda,
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.
,
Pubmed Pongs,
Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.
1988,
Pubmed Rehm,
Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I.
1988,
Pubmed Rehm,
The receptor site for the bee venom mast cell degranulating peptide. Affinity labeling and evidence for a common molecular target for mast cell degranulating peptide and dendrotoxin I, a snake toxin active on K+ channels.
1988,
Pubmed Rudy,
Diversity and ubiquity of K channels.
1988,
Pubmed Rudy,
At least two mRNA species contribute to the properties of rat brain A-type potassium channels expressed in Xenopus oocytes.
1988,
Pubmed
,
Xenbase Sands,
Charybdotoxin blocks voltage-gated K+ channels in human and murine T lymphocytes.
1989,
Pubmed Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed Schwarz,
Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.
1988,
Pubmed Schweitz,
Charybdotoxin blocks dendrotoxin-sensitive voltage-activated K+ channels.
1989,
Pubmed Stühmer,
Potassium channels expressed from rat brain cDNA have delayed rectifier properties.
1988,
Pubmed
,
Xenbase Stühmer,
Structural parts involved in activation and inactivation of the sodium channel.
1989,
Pubmed
,
Xenbase Stühmer,
Patch clamp characterization of sodium channels expressed from rat brain cDNA.
1987,
Pubmed
,
Xenbase Swenson,
K+ channels close more slowly in the presence of external K+ and Rb+.
1981,
Pubmed Tanabe,
Primary structure of the receptor for calcium channel blockers from skeletal muscle.
,
Pubmed Tempel,
Cloning of a probable potassium channel gene from mouse brain.
1988,
Pubmed Timpe,
Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes.
1988,
Pubmed
,
Xenbase Timpe,
Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes.
1988,
Pubmed
,
Xenbase
