Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
EMBO J
1989 Oct 01;810:2983-8. doi: 10.1002/j.1460-2075.1989.tb08448.x.
Show Gene links
Show Anatomy links
An antisense transcript from the Xenopus laevis bFGF gene coding for an evolutionarily conserved 24 kd protein.
Volk R, Köster M, Pöting A, Hartmann L, Knöchel W.
???displayArticle.abstract???
Screening of a Xenopus laevis oocyte cDNA library with a rat basic fibroblast growth factor (bFGF) cDNA led to the isolation of a 1.35 kb sequence containing exon III of the bFGF gene. Reverse complementary listing of this sequence revealed a polyadenylated transcript with an open reading frame coding for an unknown protein of mol. wt 24,292 daltons. The coding part of bFGF exon III is located in this putative mRNA in opposite direction within the 3' untranslated region. By hybridization studies on transcription orientation with single-stranded probes it could be proven that this transcript actually represents an antisense transcript to part of the Xenopus bFGF gene. Sequence organization on corresponding genomic fragments revealed that it is processed from a larger precursor by splicing mechanisms. Sequence comparison with elongated transcripts from the bFGF gene in human hepatoma has shown that the gene coding for the antisense mRNA is evolutionarily conserved.
Abraham,
Human basic fibroblast growth factor: nucleotide sequence and genomic organization.
1986, Pubmed
Abraham,
Human basic fibroblast growth factor: nucleotide sequence and genomic organization.
1986,
Pubmed Abraham,
Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor.
1986,
Pubmed Adelman,
Two mammalian genes transcribed from opposite strands of the same DNA locus.
1987,
Pubmed Bass,
An unwinding activity that covalently modifies its double-stranded RNA substrate.
1988,
Pubmed
,
Xenbase Bentley,
A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells.
,
Pubmed Bisbee,
Albumin phylogeny for clawed frogs (Xenopus).
1977,
Pubmed
,
Xenbase Born,
An embryonic inducing factor: isolation by high performance liquid chromatography and chemical properties.
1985,
Pubmed Grunz,
Induction of mesodermal tissues by acidic and basic heparin binding growth factors.
1988,
Pubmed
,
Xenbase Henikoff,
Gene within a gene: nested Drosophila genes encode unrelated proteins on opposite DNA strands.
1986,
Pubmed Kimelman,
The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer.
1988,
Pubmed
,
Xenbase Kimelman,
Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo.
1987,
Pubmed
,
Xenbase Knöchel,
Mesoderm-inducing factors. Their possible relationship to heparin-binding growth factors and transforming growth factor-beta.
1987,
Pubmed Knöchel,
Globin evolution in the genus Xenopus: comparative analysis of cDNAs coding for adult globin polypeptides of Xenopus borealis and Xenopus tropicalis.
1986,
Pubmed
,
Xenbase Knöchel,
Embryonic inducers, growth factors, transcription factors and oncogenes.
1989,
Pubmed Köster,
The finger motif defines a multigene family represented in the maternal mRNA of Xenopus laevis oocytes.
1988,
Pubmed
,
Xenbase Kurokawa,
Nucleotide sequence of rat basic fibroblast growth factor cDNA.
1988,
Pubmed Mercola,
Growth factor superfamilies and mammalian embryogenesis.
1988,
Pubmed Messing,
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.
1982,
Pubmed Miyajima,
Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.
1989,
Pubmed Nepveu,
Intragenic pausing and anti-sense transcription within the murine c-myc locus.
1986,
Pubmed Prats,
High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.
1989,
Pubmed Rosa,
Mesoderm induction in amphibians: the role of TGF-beta 2-like factors.
1988,
Pubmed
,
Xenbase Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed Slack,
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors.
,
Pubmed
,
Xenbase Smith,
A mesoderm-inducing factor is produced by Xenopus cell line.
1987,
Pubmed
,
Xenbase Smith,
Purification, partial characterization and biological effects of the XTC mesoderm-inducing factor.
1988,
Pubmed
,
Xenbase Spencer,
Overlapping transcription units in the dopa decarboxylase region of Drosophila.
,
Pubmed Wagner,
A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs.
1989,
Pubmed
,
Xenbase Williams,
A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3' ends.
,
Pubmed
