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We have identified the mouse Mos-encoded protein product, p39mos, in maturing mouse oocytes and have shown that it is indistinguishable from the product expressed in Mos-transformed NIH 3T3 cells. p39mos is detected in oocytes arrested in the first meiotic prophase, during germinal-vesicle breakdown, metaphase I, anaphase I, and in ovulated eggs. We show that microinjection of three different Mos antisense (but not sense) oligodeoxyribonucleotides into germinal vesicle-stage oocytes prevents first polar-body emission and therefore interrupted the normal progression of meiosis. These results show that in mouse oocytes, as in the amphibian Xenopus [Sagata, N., Oskarsson, M., Copeland, T., Brumbaugh, J. & Vande Woude, G.F. (1988) Nature (London) 335, 519-525], the product of Mos is necessary for normal meiotic maturation.
Blair,
Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis.
1981, Pubmed
Blair,
Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis.
1981,
Pubmed Blair,
Biological activity of cloned Moloney sarcoma virus DNA: Terminally redundant sequences may enhance transformation efficiency.
1980,
Pubmed Calarco,
Germinal vesicle breakdown in the mouse oocyte.
1972,
Pubmed Cho,
Inhibitory effect of dibutyryl cAMP on mouse oocyte maturation in vitro.
1974,
Pubmed Dash,
Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity.
1987,
Pubmed
,
Xenbase Dekel,
Rat oocyte maturation in vitro: relief of cyclic AMP inhibition by gonadotropins.
1978,
Pubmed Downs,
Hypoxanthine is the principal inhibitor of murine oocyte maturation in a low molecular weight fraction of porcine follicular fluid.
1985,
Pubmed Downs,
Induction of maturation in cumulus cell-enclosed mouse oocytes by follicle-stimulating hormone and epidermal growth factor: evidence for a positive stimulus of somatic cell origin.
1988,
Pubmed Dunphy,
The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis.
1988,
Pubmed
,
Xenbase Eckstein,
Nucleoside phosphorothioates.
1985,
Pubmed Eppig,
The effect of hypoxanthine on mouse oocyte growth and development in vitro: maintenance of meiotic arrest and gonadotropin-induced oocyte maturation.
1987,
Pubmed Froehler,
Synthesis of DNA via deoxynucleoside H-phosphonate intermediates.
1986,
Pubmed Gautier,
Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+.
1988,
Pubmed
,
Xenbase Goldman,
Expression of c-mos RNA in germ cells of male and female mice.
1987,
Pubmed Hanks,
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
1988,
Pubmed Hann,
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas.
1988,
Pubmed
,
Xenbase Hashimoto,
Regulation of meiotic metaphase by a cytoplasmic maturation-promoting factor during mouse oocyte maturation.
1988,
Pubmed Herzog,
Identification of the protein product of the c-mos proto-oncogene in mouse testes.
1988,
Pubmed Jessus,
Specific inhibition of endogenous beta-tubulin synthesis in Xenopus oocytes by anti-messenger oligodeoxynucleotides.
1988,
Pubmed
,
Xenbase Jones,
Identification and molecular cloning of Moloney mouse sarcoma virus-specific sequences from uninfected mouse cells.
1980,
Pubmed Kawasaki,
Quantitative hybridization-arrest of mRNA in Xenopus oocytes using single-stranded complementary DNA or oligonucleotide probes.
1985,
Pubmed
,
Xenbase Keshet,
Developmental regulation of ovarian-specific Mos expression.
1988,
Pubmed Kishimoto,
Generality of the action of various maturation-promoting factors.
1982,
Pubmed
,
Xenbase Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
Pubmed Lee,
Cell cycle control genes in fission yeast and mammalian cells.
1988,
Pubmed Magnusson,
Inhibition of maturation and metabolism in rat oocytes by cyclic amp.
1977,
Pubmed Marcus-Sekura,
Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages.
1987,
Pubmed Masui,
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.
1971,
Pubmed Maxwell,
Serine kinase activity associated with Maloney murine sarcoma virus-124-encoded p37mos.
1985,
Pubmed Maxwell,
A cAMP-independent serine/threonine kinase activity is associated with the mos sequences of ts110 Moloney murine sarcoma virus-encoded P85gag-mos.
1985,
Pubmed Mutter,
Distinct developmental patterns of c-mos protooncogene expression in female and male mouse germ cells.
1987,
Pubmed Oskarsson,
Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus.
1980,
Pubmed Papkoff,
The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein.
1983,
Pubmed Papkoff,
Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus.
1982,
Pubmed Papkoff,
Analysis of transforming gene products from Moloney murine sarcoma virus.
1981,
Pubmed Propst,
Expression of c-mos proto-oncogene transcripts in mouse tissues.
,
Pubmed Propst,
c-mos proto-oncogene RNA transcripts in mouse tissues: structural features, developmental regulation, and localization in specific cell types.
1987,
Pubmed Russell,
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog.
1987,
Pubmed Sagata,
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.
1988,
Pubmed
,
Xenbase Schmidt,
Chicken homolog of the mos proto-oncogene.
1988,
Pubmed Schroeder,
The developmental capacity of mouse oocytes that matured spontaneously in vitro is normal.
1984,
Pubmed Seth,
Nucleoside triphosphate-dependent DNA-binding properties of mos protein.
1987,
Pubmed Seth,
Nucleotide sequence and biochemical activities of the Moloney murine sarcoma virus strain HT-1 mos gene.
1985,
Pubmed Shuttleworth,
Antisense oligonucleotide-directed cleavage of mRNA in Xenopus oocytes and eggs.
1988,
Pubmed
,
Xenbase Singh,
Moloney murine sarcoma virus encoded p37mos expressed in yeast has protein kinase activity.
1986,
Pubmed Smith,
The interaction of steroids with Rana pipiens Oocytes in the induction of maturation.
1971,
Pubmed Strickland,
Antisense RNA directed against the 3' noncoding region prevents dormant mRNA activation in mouse oocytes.
1988,
Pubmed Sunkara,
Mitotic factors from mammalian cells induce germinal vesicle breakdown and chromosome condensation in amphibian oocytes.
1979,
Pubmed
,
Xenbase Van Beveren,
Nucleotide sequence of the genome of a murine sarcoma virus.
1981,
Pubmed Wassarman,
Meiotic maturation of mouse oocytes in vitro: inhibition of maturation at specific stages of nuclear progression.
1976,
Pubmed Watson,
Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.
1982,
Pubmed Wood,
Mouse c-mos oncogene activation is prevented by upstream sequences.
1984,
Pubmed
