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XB-ART-26758
Nature 1989 May 25;3396222:280-6. doi: 10.1038/339280a0.
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The role of cyclin synthesis and degradation in the control of maturation promoting factor activity.

Murray AW, Solomon MJ, Kirschner MW.


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We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.

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