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XB-ART-26827
FEBS Lett 1989 Apr 10;2471:17-21.
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Spontaneous polymerization of the antibiotic peptide magainin 2.

Urrutia R, Cruciani RA, Barker JL, Kachar B.


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We describe here the ability of the magainin 2 peptide to assemble spontaneously into characteristic 13-nm diameter filaments having a 30 nm periodic helical substructure. Optimal conditions for extensive polymerization into filaments of several hundred microns required low pH and high ionic strength. Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities.

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Species referenced: Xenopus laevis
Genes referenced: magainins