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XB-ART-269
Dev Cell 2006 Jun 01;106:687-8. doi: 10.1016/j.devcel.2006.05.007.
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Regulation of the Wnt/beta-catenin pathway by redox signaling.

Korswagen HC.


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Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al.,2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/beta-catenin pathway. This work provides interesting new insight into cross-talk between redox and Wnt/beta-catenin signaling in normal physiology and cancer.

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Species referenced: Xenopus
Genes referenced: tbx2

References :
Funato, The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled. 2006, Pubmed, Xenbase