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We have previously shown that an in vivo administration of neurotensin (NT) stimulates contraction of dog gallbladder (GB), but produces dilatation of GB in humans. The objective of this study was to examine the effect of NT on human, dog, guinea pig, and rabbit GB in vitro, in order to delineate direct versus indirect actions of NT in different species and to evaluate the structure-activity relationships of NT. The effect of NT on the canine sphincter of Oddi (SOD) was also examined in vitro. Isolated longitudinal strips of GB from the four species given above and SOD from dogs were suspended in oxygenated Krebs buffer, and the isometric tension responses to various doses of NT, NT 8-13, NT 1-11, and xenopsin (XP) were determined. All the NT homologs, except NT 1-11, stimulated contraction of the dog GB and SOD in a dose-dependent manner. NT also caused dose-related stimulation of GB contraction from guinea pigs but did not stimulate or depress the contractile activity of human and rabbit GB strips. These results suggest that NT action on GB contraction is species-specific. Tetrodotoxin did not modify the contraction of dog GB and SOD in response to NT, indicating that NT mediates its contractile effects directly. The relaxing effect of NT on GB of humans in vivo, as previously reported by us, thus appears to be an indirect action.(ABSTRACT TRUNCATED AT 250 WORDS)
Andersson,
Inhibition of gastric acid secretion in dogs by neurotensin.
1976, Pubmed
Andersson,
Inhibition of gastric acid secretion in dogs by neurotensin.
1976,
Pubmed Ayres,
The effects of neurotensin on gastrointestinal motility in rodents.
1985,
Pubmed Baca,
Effect of neurotensin on exocrine pancreatic secretion in dogs.
1982,
Pubmed Berry,
The assay of endogenous cholecystokinin and factors influencing its release in the dog and cat.
1971,
Pubmed Blackburn,
Effect of neurotensin on gastric function in man.
1980,
Pubmed Brown,
Neurotensin.
1982,
Pubmed Carraway,
The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami.
1973,
Pubmed Carraway,
Amphibian neurotensin (NT) is not xenopsin (XP): dual presence of NT-like and XP-like peptides in various amphibia.
1982,
Pubmed
,
Xenbase Doyle,
Distribution of neurotensin in the canine gastrointestinal tract.
1985,
Pubmed Feurle,
Xenopsin stimulates exocrine pancreatic secretion in the dog.
1982,
Pubmed
,
Xenbase Feurle,
Evidence for the presence of xenopsin-related peptide(s) in the gastric mucosa of mammals.
1985,
Pubmed
,
Xenbase Goedert,
The comparative distribution of xenopsin- and neurotensin-like immunoreactivity in Xenopus laevis and rat tissues.
1984,
Pubmed
,
Xenbase Hammer,
Isolation of human intestinal neurotensin.
1980,
Pubmed Hellström,
Effects of neurotensin, substance P and methionine-enkephalin on colonic motility.
1981,
Pubmed Helmstaedter,
Localization of neurotensin-immunoreactive cells in the small intestine of man and various mammals.
1977,
Pubmed Holzer,
A study of the concentrations of substance P and neurotensin in the gastrointestinal tract of various mammals.
1982,
Pubmed Huidobro-Toro,
Excitatory neurotensin receptors on the smooth muscle of the rat fundus: possible implications in gastric motility.
1985,
Pubmed Ishida,
Comparison studies of neurotensin and xenopsin upon pancreatic secretion in the dog [proceedings].
1976,
Pubmed Kawanishi,
The effects of xenopsin of endocrine pancreas and gastric antrum in dogs.
1978,
Pubmed
,
Xenbase Kitabgi,
Neurotensin binding to extraneural and neural receptors: comparison with biological activity and structure--activity relationships.
1980,
Pubmed Kitabgi,
Isolation of a tridecapeptide from bovine intestinal tissue and its partial characterization as neurotensin.
1976,
Pubmed Lonovics,
Release of pancreatic polypeptide in humans by infusion of cholecystokinin.
1980,
Pubmed Polak,
Specific localisation of neurotensin to the N cell in human intestine by radioimmunoassay and immunocytochemistry.
1977,
Pubmed Quirion,
The stimulatory effects of neurotensin and related peptides in rat stomach strips and guinea-pig atria.
1980,
Pubmed Rosell,
Plasma concentration of neurotensin-like immunoreactivity (NTLI) and lower esophageal sphincter (LES) pressure in man following infusion of (Gln4)-neurotensin.
1980,
Pubmed Rosell,
The role of neurotensin in gut motility.
1984,
Pubmed Sakamoto,
Role of neurotensin in pancreatic secretion.
1984,
Pubmed Toouli,
In-vitro motility studies on the canine and human extrahepatic biliary tracts.
1971,
Pubmed Toouli,
Actions of cholecystokinin-pancreozymin, secretin and gastrin on extra-hepatic biliary tract motility in vitro.
1972,
Pubmed Walker,
The role of neurotensin in human gallbladder motility.
1985,
Pubmed Zinner,
Effect of xenopsin on blood flow, hormone release, and acid secretion.
1982,
Pubmed
,
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