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Eur Biophys J
1989 Jan 01;172:53-9. doi: 10.1007/bf00257102.
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Quantal charge redistributions accompanying the structural transitions of sodium channels.
Conti F, Stühmer W.
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Asymmetric displacement currents, Ig, associated with the gating of nerve sodium channels have been recorded in cell-attached macropatches of Xenopus laevis oocytes injected with exogenous mRNA coding for rat-brain-II sodium channels. The Ig properties were found to be similar to those of gating currents previously observed in native nerve preparations. Ig fluctuations were measured in order to ascertain the discreteness of the conformational changes which precede the channel opening. The auto-correlation of the fluctuations is consistent with a shot-like character of the elementary Ig contributions. The variance of the fluctuations indicates that most of the gating-charge movement that accompanies the activation of a single sodium channel occurs in 2 to 3 brief packets, each carrying an equivalent of about 2.3 electron charges.
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,
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1975,
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1980,
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1975,
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Nerve fiber behaviour in heavy water under voltage-clamp.
1968,
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1982,
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1987,
Pubmed French,
Sodium channel gating: models, mimics, and modifiers.
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1981,
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A quantitative description of membrane current and its application to conduction and excitation in nerve.
1952,
Pubmed Horn,
Statistical properties of single sodium channels.
1984,
Pubmed Katz,
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1970,
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The Croonian Lecture, 1983. Voltage-gated ion channels in the nerve membrane.
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Pubmed Keynes,
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1976,
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1986,
Pubmed
,
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1974,
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1976,
Pubmed Neher,
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Pubmed Neumcke,
Asymmetrical displacement current and its relation with the activation of sodium current in the membrane of frog myelinated nerve.
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Expression of functional sodium channels from cloned cDNA.
,
Pubmed
,
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1985,
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1987,
Pubmed
,
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,
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