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XB-ART-27183
FEBS Lett 1988 Nov 21;2401-2:95-100.
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Different sensitivities to agonist of muscarinic acetylcholine receptor subtypes.

Bujo H, Nakai J, Kubo T, Fukuda K, Akiba I, Maeda A, Mishina M, Numa S.


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Muscarinic acetylcholine receptor (mAChR) III expressed in Xenopus oocytes, like mAChR I, mediates activation of a Ca2+-dependent Cl- current, whereas mAChR IV, like mAChR II, principally induces activation of Na+ and K+ currents in a Ca2+-independent manner. mAChR III has a sensitivity to agonist of about one order of magnitude higher than that of mAChR I in mediating the Ca2+-dependent current response in Xenopus oocytes and in stimulating phosphoinositide hydrolysis in NG108-15 neuroblastoma-glioma hybrid cells. The agonist-binding affinity of mAChR III is also about one order of magnitude higher than that of mAChR I.

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