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The X.laevis XlHbox 1 gene uses two functional promoters to produce a short and a long protein, both containing the same homeodomain. In this report we use specific antibodies to localize both proteins in frog embryos. The antibodies also recognize the homologous proteins in mouse embryos. In both mammalian and amphibian embryos, expression of the long protein starts more posteriorly than that of the short protein. This difference in spatial expression applies to the nervous system, the segmented mesoderm and the internal organs. This suggests that each promoter from this gene has precisely restricted regions of expression along the anterior-posterior axis of the embryo. Because the long and short proteins share a common DNA-binding specificity but differ by an 82 amino acid domain, their differential distribution may have distinct developmental consequences.
Awgulewitsch,
Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.
, Pubmed
Awgulewitsch,
Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.
,
Pubmed Bikel,
Purification of biologically active simian virus 40 small tumor antigen.
1983,
Pubmed Breier,
Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster.
1988,
Pubmed Bürglin,
The nuclear migration signal of Xenopus laevis nucleoplasmin.
1987,
Pubmed
,
Xenbase Cannizzaro,
Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13.
1987,
Pubmed Carrasco,
Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes.
1984,
Pubmed
,
Xenbase Carrasco,
Localization of Xenopus homoeo-box gene transcripts during embryogenesis and in the adult nervous system.
1987,
Pubmed
,
Xenbase Cho,
Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity.
1988,
Pubmed
,
Xenbase Condie,
Posterior expression of a homeobox gene in early Xenopus embryos.
1987,
Pubmed
,
Xenbase Deutsch,
Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development.
1988,
Pubmed Dony,
Specific expression of the Hox 1.3 homeo box gene in murine embryonic structures originating from or induced by the mesoderm.
1987,
Pubmed Fibi,
Coding sequence and expression of the homeobox gene Hox 1.3.
1988,
Pubmed Fritz,
Xenopus homeobox-containing cDNAs expressed in early development.
1988,
Pubmed
,
Xenbase Gaunt,
Homoeobox gene expression in mouse embryos varies with position by the primitive streak stage.
,
Pubmed Gaunt,
Homoeobox gene Hox-1.5 expression in mouse embryos: earliest detection by in situ hybridization is during gastrulation.
1987,
Pubmed Holland,
Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis.
1988,
Pubmed Kessel,
Primary structure and nuclear localization of a murine homeodomain protein.
1987,
Pubmed Krumlauf,
Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1.
1987,
Pubmed Lambert,
A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator.
1987,
Pubmed Martin,
Nomenclature for homoeobox-containing genes.
,
Pubmed Odenwald,
Expression of a homeo domain protein in noncontact-inhibited cultured cells and postmitotic neurons.
1987,
Pubmed Rüther,
Easy identification of cDNA clones.
1983,
Pubmed Sharpe,
A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction.
1987,
Pubmed
,
Xenbase Sharpe,
Isolation and expression of a new mouse homeobox gene.
1988,
Pubmed
,
Xenbase Simeone,
Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.
1987,
Pubmed Slack,
Homoeotic transformations in man: implications for the mechanism of embryonic development and for the organization of epithelia.
1985,
Pubmed Toth,
Region-specific expression of mouse homeobox genes in the embryonic mesoderm and central nervous system.
1987,
Pubmed Ullmann,
One-step purification of hybrid proteins which have beta-galactosidase activity.
1984,
Pubmed Utset,
Region-specific expression of two mouse homeo box genes.
1987,
Pubmed Verbout,
The development of the vertebral column.
1985,
Pubmed Zeller,
Nucleocytoplasmic distribution of snRNPs and stockpiled snRNA-binding proteins during oogenesis and early development in Xenopus laevis.
1983,
Pubmed
,
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