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Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2.
Featherstone MS, Baron A, Gaunt SJ, Mattei MG, Duboule D.
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We have isolated a murine homeobox-containing gene, Hox-5.1, by virtue of its relatedness to the Hox-1.4 gene. In situ hybridization to metaphase spreads mapped Hox-5.1 to band D of mouse chromosome 2. Sequence comparisons indicate that Hox-5.1 is the murine homolog of the human C13 homeobox-containing gene. Hox-5.1 also bears significant similarity to the Xenopus Xhox-1A homeobox-containing gene and the Drosophila deformed homeotic gene at N-terminal and homeobox regions. Hox-5.1 transcripts were detected in mouse embryos, in adult mouse testis, kidney, heart, and intestine, and in mouse embryonal carcinoma cells treated with retinoic acid. In situ hybridization to sections from whole mouse embryos revealed Hox-5.1 expression in spinal cord and prevertebrae.
Awgulewitsch,
Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.
, Pubmed
Awgulewitsch,
Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.
,
Pubmed Baron,
Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex.
1987,
Pubmed Breier,
Sequential expression of murine homeo box genes during F9 EC cell differentiation.
1986,
Pubmed
,
Xenbase Bućan,
Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.
1986,
Pubmed Cannizzaro,
Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13.
1987,
Pubmed Colberg-Poley,
Clustered homeo boxes are differentially expressed during murine development.
1985,
Pubmed Colberg-Poley,
Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells.
,
Pubmed Deschamps,
Abundant expression of homeobox genes in mouse embryonal carcinoma cells correlates with chemically induced differentiation.
1987,
Pubmed Desplan,
The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity.
,
Pubmed Dony,
Specific expression of the Hox 1.3 homeo box gene in murine embryonic structures originating from or induced by the mesoderm.
1987,
Pubmed Duboule,
A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus.
1986,
Pubmed
,
Xenbase Duboule,
DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues.
1987,
Pubmed Fainsod,
Expression of the murine homeo box gene Hox 1.5 during embryogenesis.
1987,
Pubmed Fainsod,
The homeo domain of a murine protein binds 5' to its own homeo box.
1986,
Pubmed Gaunt,
Homoeobox gene expression in mouse embryos varies with position by the primitive streak stage.
,
Pubmed Gaunt,
Homoeobox gene Hox-1.5 expression in mouse embryos: earliest detection by in situ hybridization is during gastrulation.
1987,
Pubmed Gehring,
Homeo boxes in the study of development.
1987,
Pubmed Gehring,
The homeo box: a key to the understanding of development?
1985,
Pubmed Hart,
Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus.
1985,
Pubmed Hart,
Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons.
1987,
Pubmed
,
Xenbase Harvey,
Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products.
1986,
Pubmed
,
Xenbase Hauser,
Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.
1985,
Pubmed Jackson,
A mouse homoeo box gene is expressed during embryogenesis and in adult kidney.
,
Pubmed
,
Xenbase Joyner,
Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene.
1985,
Pubmed Kessel,
Primary structure and nuclear localization of a murine homeodomain protein.
1987,
Pubmed Kozak,
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.
1987,
Pubmed Laughon,
Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins.
,
Pubmed Levine,
Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.
1984,
Pubmed Lonai,
New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis.
1987,
Pubmed Martin,
Nomenclature for homoeobox-containing genes.
,
Pubmed Mattei,
DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome.
1985,
Pubmed Mavilio,
Differential and stage-related expression in embryonic tissues of a new human homoeobox gene.
,
Pubmed
,
Xenbase McBurney,
Isolation of male embryonal carcinoma cells and their chromosome replication patterns.
1982,
Pubmed McGinnis,
Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila.
1984,
Pubmed McGinnis,
A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans.
1984,
Pubmed Meijlink,
A mouse homeobox containing gene on chromosome 11: sequence and tissue-specific expression.
1987,
Pubmed Odenwald,
Expression of a homeo domain protein in noncontact-inhibited cultured cells and postmitotic neurons.
1987,
Pubmed Poustka,
Selective isolation of cosmid clones by homologous recombination in Escherichia coli.
1984,
Pubmed Rabin,
Cognate homeo-box loci mapped on homologous human and mouse chromosomes.
1986,
Pubmed Regulski,
Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development.
1987,
Pubmed
,
Xenbase Rubin,
A mouse homeo box gene is expressed in spermatocytes and embryos.
1986,
Pubmed Scott,
Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.
1984,
Pubmed Sharpe,
Isolation and expression of a new mouse homeobox gene.
1988,
Pubmed
,
Xenbase Shepherd,
Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins.
,
Pubmed
,
Xenbase Theiler,
Development of rachiterata, a mutation in the house mouse with 6 cervical vertebrae.
1974,
Pubmed Toth,
Region-specific expression of mouse homeobox genes in the embryonic mesoderm and central nervous system.
1987,
Pubmed Utset,
Region-specific expression of two mouse homeo box genes.
1987,
Pubmed Varnum,
Rachiterata: a new skeletal mutation on chromosome 2 of the mouse.
1974,
Pubmed Wolgemuth,
Isolation of a mouse cDNA coding for a developmentally regulated, testis-specific transcript containing homeo box homology.
1986,
Pubmed
